STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaA-2Unannotated protein. (245 aa)    
Predicted Functional Partners:
guaB
Unannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.931
guaC
Unannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
  
 
 0.868
gmk
Unannotated protein; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.852
thrA
Unannotated protein; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.822
metL
Unannotated protein; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.822
kdsD2
Unannotated protein.
  
 
 0.796
gltB
Unannotated protein.
  
 
 0.777
apt
Unannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.760
gpt
Unannotated protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
  
 
 0.760
kdsD
Unannotated protein.
    
 0.741
Your Current Organism:
Klebsiella pneumoniae rhinoscleromatis
NCBI taxonomy Id: 667127
Other names: K. pneumoniae subsp. rhinoscleromatis ATCC 13884, Klebsiella pneumoniae subsp. rhinoscleromatis ATCC 13884, Klebsiella pneumoniae subsp. rhinoscleromatis str. ATCC 13884, Klebsiella pneumoniae subsp. rhinoscleromatis strain ATCC 13884
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