| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NadR | cpdB | HMPREF0621_1980 | HMPREF0621_0491 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.414 |
| NadR | guaA | HMPREF0621_1980 | HMPREF0621_0382 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.427 |
| NadR | surE | HMPREF0621_1980 | HMPREF0621_0793 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| NadR | ushA | HMPREF0621_1980 | HMPREF0621_0087 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.928 |
| NadR | yjjG | HMPREF0621_1980 | HMPREF0621_0536 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | HAD hydrolase, TIGR02254 family; COG: COG1011; Pfam: PF00702; InterPro: IPR011951. | 0.912 |
| cdd | cpdB | HMPREF0621_1546 | HMPREF0621_0491 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.904 |
| cdd | guaA | HMPREF0621_1546 | HMPREF0621_0382 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.416 |
| cdd | surE | HMPREF0621_1546 | HMPREF0621_0793 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.918 |
| cdd | tdk | HMPREF0621_1546 | HMPREF0621_0048 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Thymidine kinase; COG: COG1435; Pfam: PF00265; InterPro: IPR001267. | 0.920 |
| cdd | udk | HMPREF0621_1546 | HMPREF0621_0274 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Uridine kinase; COG: COG0572; Pfam: PF00485; InterPro: IPR000764. | 0.924 |
| cdd | ushA | HMPREF0621_1546 | HMPREF0621_0087 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.909 |
| cdd | yjjG | HMPREF0621_1546 | HMPREF0621_0536 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | HAD hydrolase, TIGR02254 family; COG: COG1011; Pfam: PF00702; InterPro: IPR011951. | 0.900 |
| cpdB | NadR | HMPREF0621_0491 | HMPREF0621_1980 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.414 |
| cpdB | cdd | HMPREF0621_0491 | HMPREF0621_1546 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | 0.904 |
| cpdB | surE | HMPREF0621_0491 | HMPREF0621_0793 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.906 |
| cpdB | udk | HMPREF0621_0491 | HMPREF0621_0274 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Uridine kinase; COG: COG0572; Pfam: PF00485; InterPro: IPR000764. | 0.902 |
| cpdB | ushA | HMPREF0621_0491 | HMPREF0621_0087 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | Bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.929 |
| cpdB | yjjG | HMPREF0621_0491 | HMPREF0621_0536 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | HAD hydrolase, TIGR02254 family; COG: COG1011; Pfam: PF00702; InterPro: IPR011951. | 0.904 |
| guaA | NadR | HMPREF0621_0382 | HMPREF0621_1980 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.427 |
| guaA | cdd | HMPREF0621_0382 | HMPREF0621_1546 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | 0.416 |