| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CopA | EEX51356.1 | HMPREF0621_0162 | HMPREF0621_0160 | Copper-exporting ATPase; COG: COG2217; Pfam: PF00403,PF00122,PF00702; InterPro: IPR001757. | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | 0.432 |
| CopA | merP2 | HMPREF0621_0162 | HMPREF0621_0161 | Copper-exporting ATPase; COG: COG2217; Pfam: PF00403,PF00122,PF00702; InterPro: IPR001757. | Heavy metal-associated domain protein; COG: COG2608; Pfam: PF00403; InterPro: IPR001757. | 0.924 |
| EEX51356.1 | CopA | HMPREF0621_0160 | HMPREF0621_0162 | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | Copper-exporting ATPase; COG: COG2217; Pfam: PF00403,PF00122,PF00702; InterPro: IPR001757. | 0.432 |
| EEX51356.1 | merP2 | HMPREF0621_0160 | HMPREF0621_0161 | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | Heavy metal-associated domain protein; COG: COG2608; Pfam: PF00403; InterPro: IPR001757. | 0.583 |
| EEX51356.1 | pyrD | HMPREF0621_0160 | HMPREF0621_1364 | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.477 |
| EEX51356.1 | pyrE | HMPREF0621_0160 | HMPREF0621_0540 | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.492 |
| EEX51356.1 | pyrF-2 | HMPREF0621_0160 | HMPREF0621_0992 | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.490 |
| EEX51356.1 | yhhQ | HMPREF0621_0160 | HMPREF0621_0159 | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | Putative membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. | 0.502 |
| merP2 | CopA | HMPREF0621_0161 | HMPREF0621_0162 | Heavy metal-associated domain protein; COG: COG2608; Pfam: PF00403; InterPro: IPR001757. | Copper-exporting ATPase; COG: COG2217; Pfam: PF00403,PF00122,PF00702; InterPro: IPR001757. | 0.924 |
| merP2 | EEX51356.1 | HMPREF0621_0161 | HMPREF0621_0160 | Heavy metal-associated domain protein; COG: COG2608; Pfam: PF00403; InterPro: IPR001757. | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | 0.583 |
| pyrD | EEX51356.1 | HMPREF0621_1364 | HMPREF0621_0160 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | 0.477 |
| pyrD | pyrE | HMPREF0621_1364 | HMPREF0621_0540 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.992 |
| pyrD | pyrF-2 | HMPREF0621_1364 | HMPREF0621_0992 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.936 |
| pyrE | EEX51356.1 | HMPREF0621_0540 | HMPREF0621_0160 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | 0.492 |
| pyrE | pyrD | HMPREF0621_0540 | HMPREF0621_1364 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.992 |
| pyrE | pyrF-2 | HMPREF0621_0540 | HMPREF0621_0992 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.992 |
| pyrF-2 | EEX51356.1 | HMPREF0621_0992 | HMPREF0621_0160 | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | 0.490 |
| pyrF-2 | pyrD | HMPREF0621_0992 | HMPREF0621_1364 | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.936 |
| pyrF-2 | pyrE | HMPREF0621_0992 | HMPREF0621_0540 | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.992 |
| yhhQ | EEX51356.1 | HMPREF0621_0159 | HMPREF0621_0160 | Putative membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. | Hypothetical protein; Pfam: PF04657; InterPro: IPR006750. | 0.502 |