node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dacA | mrdA | HMPREF0621_0196 | HMPREF0621_0193 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.710 |
dacA | mrdB | HMPREF0621_0196 | HMPREF0621_0194 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.716 |
dacA | rlmH | HMPREF0621_0196 | HMPREF0621_0192 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | rRNA large subunit m3Psi methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.759 |
dacA | rlpA | HMPREF0621_0196 | HMPREF0621_0195 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.719 |
dacA | ybeB | HMPREF0621_0196 | HMPREF0621_0191 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.569 |
ftsI | ftsW | HMPREF0621_0343 | HMPREF0621_0348 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.977 |
ftsI | mrcB | HMPREF0621_0343 | HMPREF0621_0941 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.759 |
ftsI | mrdA | HMPREF0621_0343 | HMPREF0621_0193 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.938 |
ftsI | mrdB | HMPREF0621_0343 | HMPREF0621_0194 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.889 |
ftsI | mreB | HMPREF0621_0343 | HMPREF0621_0228 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Cell shape determining protein, MreB/Mrl family; COG: COG1077; Pfam: PF06723; InterPro: IPR004753. | 0.633 |
ftsI | mreC | HMPREF0621_0343 | HMPREF0621_0229 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Rod shape-determining protein MreC; COG: COG1792; Pfam: PF04085; InterPro: IPR005223. | 0.661 |
ftsW | ftsI | HMPREF0621_0348 | HMPREF0621_0343 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | 0.977 |
ftsW | mrcB | HMPREF0621_0348 | HMPREF0621_0941 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.572 |
ftsW | mrdA | HMPREF0621_0348 | HMPREF0621_0193 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.868 |
ftsW | mrdB | HMPREF0621_0348 | HMPREF0621_0194 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.402 |
ftsW | mreB | HMPREF0621_0348 | HMPREF0621_0228 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Cell shape determining protein, MreB/Mrl family; COG: COG1077; Pfam: PF06723; InterPro: IPR004753. | 0.699 |
ftsW | mreC | HMPREF0621_0348 | HMPREF0621_0229 | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | Rod shape-determining protein MreC; COG: COG1792; Pfam: PF04085; InterPro: IPR005223. | 0.495 |
mrcB | ftsI | HMPREF0621_0941 | HMPREF0621_0343 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | 0.759 |
mrcB | ftsW | HMPREF0621_0941 | HMPREF0621_0348 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.572 |
mrcB | mrdA | HMPREF0621_0941 | HMPREF0621_0193 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.751 |