| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX51393.1 | dacA | HMPREF0621_0197 | HMPREF0621_0196 | Hypothetical protein; COG: COG2921; Pfam: PF04359; InterPro: IPR007454; Belongs to the UPF0250 family. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | 0.581 |
| EEX51393.1 | lipA | HMPREF0621_0197 | HMPREF0621_0199 | Hypothetical protein; COG: COG2921; Pfam: PF04359; InterPro: IPR007454; Belongs to the UPF0250 family. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.669 |
| EEX51393.1 | lipB | HMPREF0621_0197 | HMPREF0621_0198 | Hypothetical protein; COG: COG2921; Pfam: PF04359; InterPro: IPR007454; Belongs to the UPF0250 family. | Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.858 |
| EEX51393.1 | rlpA | HMPREF0621_0197 | HMPREF0621_0195 | Hypothetical protein; COG: COG2921; Pfam: PF04359; InterPro: IPR007454; Belongs to the UPF0250 family. | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.513 |
| aceF | lipA | HMPREF0621_1178 | HMPREF0621_0199 | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.473 |
| aceF | lipB | HMPREF0621_1178 | HMPREF0621_0198 | Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.550 |
| dacA | EEX51393.1 | HMPREF0621_0196 | HMPREF0621_0197 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Hypothetical protein; COG: COG2921; Pfam: PF04359; InterPro: IPR007454; Belongs to the UPF0250 family. | 0.581 |
| dacA | lipA | HMPREF0621_0196 | HMPREF0621_0199 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.452 |
| dacA | lipB | HMPREF0621_0196 | HMPREF0621_0198 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.559 |
| dacA | rlpA | HMPREF0621_0196 | HMPREF0621_0195 | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1686; Pfam: PF00768,PF07943; InterPro: IPR001967; Belongs to the peptidase S11 family. | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.719 |
| fabF | fabF2 | HMPREF0621_0660 | HMPREF0621_0663 | Beta-ketoacyl synthase, C-terminal domain protein; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 3-oxoacyl-(acyl carrier protein) synthase II; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.978 |
| fabF | fabF3 | HMPREF0621_0660 | HMPREF0621_0314 | Beta-ketoacyl synthase, C-terminal domain protein; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 3-oxoacyl-(acyl carrier protein) synthase I; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.924 |
| fabF | fabI | HMPREF0621_0660 | HMPREF0621_1762 | Beta-ketoacyl synthase, C-terminal domain protein; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Putative enoyl-[acyl-carrier-protein] reductase (NADH); COG: COG0623; InterPro: IPR016040. | 0.968 |
| fabF | lipB | HMPREF0621_0660 | HMPREF0621_0198 | Beta-ketoacyl synthase, C-terminal domain protein; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.806 |
| fabF2 | fabF | HMPREF0621_0663 | HMPREF0621_0660 | 3-oxoacyl-(acyl carrier protein) synthase II; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Beta-ketoacyl synthase, C-terminal domain protein; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.978 |
| fabF2 | fabF3 | HMPREF0621_0663 | HMPREF0621_0314 | 3-oxoacyl-(acyl carrier protein) synthase II; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 3-oxoacyl-(acyl carrier protein) synthase I; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.916 |
| fabF2 | fabI | HMPREF0621_0663 | HMPREF0621_1762 | 3-oxoacyl-(acyl carrier protein) synthase II; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Putative enoyl-[acyl-carrier-protein] reductase (NADH); COG: COG0623; InterPro: IPR016040. | 0.969 |
| fabF2 | lipB | HMPREF0621_0663 | HMPREF0621_0198 | 3-oxoacyl-(acyl carrier protein) synthase II; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.806 |
| fabF3 | fabF | HMPREF0621_0314 | HMPREF0621_0660 | 3-oxoacyl-(acyl carrier protein) synthase I; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Beta-ketoacyl synthase, C-terminal domain protein; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.924 |
| fabF3 | fabF2 | HMPREF0621_0314 | HMPREF0621_0663 | 3-oxoacyl-(acyl carrier protein) synthase I; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 3-oxoacyl-(acyl carrier protein) synthase II; COG: COG0304; Pfam: PF00109,PF02801; InterPro: IPR000794; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.916 |