| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LptG | trmJ | HMPREF0621_1747 | HMPREF0621_0293 | Permease, YjgP/YjgQ family; COG: COG0795; Pfam: PF03739; InterPro: IPR005495. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.465 |
| cysS | trmJ | HMPREF0621_0418 | HMPREF0621_0293 | cysteine--tRNA ligase; COG: COG0215; Pfam: PF01406,PF09190; InterPro: IPR002308; Belongs to the class-I aminoacyl-tRNA synthetase family. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.692 |
| iscR | iscS | HMPREF0621_0294 | HMPREF0621_0295 | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.969 |
| iscR | suhB | HMPREF0621_0294 | HMPREF0621_0292 | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Inositol monophosphatase family protein; COG: COG0483; Pfam: PF00459; InterPro: IPR000760; Belongs to the inositol monophosphatase superfamily. | 0.444 |
| iscR | trmJ | HMPREF0621_0294 | HMPREF0621_0293 | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.618 |
| iscS | iscR | HMPREF0621_0295 | HMPREF0621_0294 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.969 |
| iscS | trmJ | HMPREF0621_0295 | HMPREF0621_0293 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.519 |
| rrmJ | trmJ | HMPREF0621_1270 | HMPREF0621_0293 | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.508 |
| suhB | iscR | HMPREF0621_0292 | HMPREF0621_0294 | Inositol monophosphatase family protein; COG: COG0483; Pfam: PF00459; InterPro: IPR000760; Belongs to the inositol monophosphatase superfamily. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.444 |
| suhB | trmJ | HMPREF0621_0292 | HMPREF0621_0293 | Inositol monophosphatase family protein; COG: COG0483; Pfam: PF00459; InterPro: IPR000760; Belongs to the inositol monophosphatase superfamily. | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | 0.545 |
| trmJ | LptG | HMPREF0621_0293 | HMPREF0621_1747 | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | Permease, YjgP/YjgQ family; COG: COG0795; Pfam: PF03739; InterPro: IPR005495. | 0.465 |
| trmJ | cysS | HMPREF0621_0293 | HMPREF0621_0418 | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | cysteine--tRNA ligase; COG: COG0215; Pfam: PF01406,PF09190; InterPro: IPR002308; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.692 |
| trmJ | iscR | HMPREF0621_0293 | HMPREF0621_0294 | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.618 |
| trmJ | iscS | HMPREF0621_0293 | HMPREF0621_0295 | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.519 |
| trmJ | rrmJ | HMPREF0621_0293 | HMPREF0621_1270 | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | 0.508 |
| trmJ | suhB | HMPREF0621_0293 | HMPREF0621_0292 | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. | Inositol monophosphatase family protein; COG: COG0483; Pfam: PF00459; InterPro: IPR000760; Belongs to the inositol monophosphatase superfamily. | 0.545 |