| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Slt | amiB | HMPREF0621_0303 | HMPREF0621_1170 | Transglycosylase SLT domain protein; COG: COG0741; Pfam: PF01464; InterPro: IPR008939. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | 0.438 |
| Slt | mtgA | HMPREF0621_0303 | HMPREF0621_0301 | Transglycosylase SLT domain protein; COG: COG0741; Pfam: PF01464; InterPro: IPR008939. | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. Belongs to the glycosyltransferase 51 family. | 0.458 |
| Slt | trpR | HMPREF0621_0303 | HMPREF0621_0302 | Transglycosylase SLT domain protein; COG: COG0741; Pfam: PF01464; InterPro: IPR008939. | Trp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription. | 0.761 |
| amiB | Slt | HMPREF0621_1170 | HMPREF0621_0303 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Transglycosylase SLT domain protein; COG: COG0741; Pfam: PF01464; InterPro: IPR008939. | 0.438 |
| amiB | ftsI | HMPREF0621_1170 | HMPREF0621_0343 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | 0.576 |
| amiB | ftsN | HMPREF0621_1170 | HMPREF0621_0138 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Cell division protein FtsN; Pfam: PF05036; InterPro: IPR007730. | 0.704 |
| amiB | mltG | HMPREF0621_1170 | HMPREF0621_0592 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.528 |
| amiB | mrdA | HMPREF0621_1170 | HMPREF0621_0193 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.573 |
| amiB | mrdB | HMPREF0621_1170 | HMPREF0621_0194 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.471 |
| amiB | mtgA | HMPREF0621_1170 | HMPREF0621_0301 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. Belongs to the glycosyltransferase 51 family. | 0.536 |
| amiB | murG | HMPREF0621_1170 | HMPREF0621_0349 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.463 |
| dacB | mtgA | HMPREF0621_1294 | HMPREF0621_0301 | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; COG: COG2027; Pfam: PF02113; InterPro: IPR000667. | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. Belongs to the glycosyltransferase 51 family. | 0.608 |
| ftsI | amiB | HMPREF0621_0343 | HMPREF0621_1170 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | 0.576 |
| ftsI | ftsN | HMPREF0621_0343 | HMPREF0621_0138 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Cell division protein FtsN; Pfam: PF05036; InterPro: IPR007730. | 0.656 |
| ftsI | mltG | HMPREF0621_0343 | HMPREF0621_0592 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.401 |
| ftsI | mrdA | HMPREF0621_0343 | HMPREF0621_0193 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.938 |
| ftsI | mrdB | HMPREF0621_0343 | HMPREF0621_0194 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.889 |
| ftsI | mtgA | HMPREF0621_0343 | HMPREF0621_0301 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. Belongs to the glycosyltransferase 51 family. | 0.502 |
| ftsI | murG | HMPREF0621_0343 | HMPREF0621_0349 | Penicillin-binding protein, transpeptidase domain protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.869 |
| ftsN | amiB | HMPREF0621_0138 | HMPREF0621_1170 | Cell division protein FtsN; Pfam: PF05036; InterPro: IPR007730. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | 0.704 |