| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| arsC2 | dapE | HMPREF0621_0360 | HMPREF0621_0361 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.658 |
| arsC2 | htpG | HMPREF0621_0360 | HMPREF0621_0359 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Hsp90 protein; Molecular chaperone. Has ATPase activity. | 0.595 |
| arsC2 | nudF | HMPREF0621_0360 | HMPREF0621_0364 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.485 |
| arsC2 | psiE | HMPREF0621_0360 | HMPREF0621_0363 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Protein PsiE; COG: COG3223; Pfam: PF06146; InterPro: IPR009315. | 0.524 |
| arsC2 | vanY | HMPREF0621_0360 | HMPREF0621_0362 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1876; Pfam: PF02557; InterPro: IPR003709. | 0.623 |
| dapE | arsC2 | HMPREF0621_0361 | HMPREF0621_0360 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | 0.658 |
| dapE | htpG | HMPREF0621_0361 | HMPREF0621_0359 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Hsp90 protein; Molecular chaperone. Has ATPase activity. | 0.457 |
| dapE | nudF | HMPREF0621_0361 | HMPREF0621_0364 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.631 |
| dapE | psiE | HMPREF0621_0361 | HMPREF0621_0363 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Protein PsiE; COG: COG3223; Pfam: PF06146; InterPro: IPR009315. | 0.686 |
| dapE | vanY | HMPREF0621_0361 | HMPREF0621_0362 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1876; Pfam: PF02557; InterPro: IPR003709. | 0.794 |
| htpG | arsC2 | HMPREF0621_0359 | HMPREF0621_0360 | Hsp90 protein; Molecular chaperone. Has ATPase activity. | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | 0.595 |
| htpG | dapE | HMPREF0621_0359 | HMPREF0621_0361 | Hsp90 protein; Molecular chaperone. Has ATPase activity. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.457 |
| htpG | vanY | HMPREF0621_0359 | HMPREF0621_0362 | Hsp90 protein; Molecular chaperone. Has ATPase activity. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1876; Pfam: PF02557; InterPro: IPR003709. | 0.445 |
| nudF | arsC2 | HMPREF0621_0364 | HMPREF0621_0360 | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | 0.485 |
| nudF | dapE | HMPREF0621_0364 | HMPREF0621_0361 | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.631 |
| nudF | psiE | HMPREF0621_0364 | HMPREF0621_0363 | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Protein PsiE; COG: COG3223; Pfam: PF06146; InterPro: IPR009315. | 0.709 |
| nudF | vanY | HMPREF0621_0364 | HMPREF0621_0362 | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1876; Pfam: PF02557; InterPro: IPR003709. | 0.631 |
| psiE | arsC2 | HMPREF0621_0363 | HMPREF0621_0360 | Protein PsiE; COG: COG3223; Pfam: PF06146; InterPro: IPR009315. | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | 0.524 |
| psiE | dapE | HMPREF0621_0363 | HMPREF0621_0361 | Protein PsiE; COG: COG3223; Pfam: PF06146; InterPro: IPR009315. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.686 |
| psiE | nudF | HMPREF0621_0363 | HMPREF0621_0364 | Protein PsiE; COG: COG3223; Pfam: PF06146; InterPro: IPR009315. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.709 |