| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NadR | nudE | HMPREF0621_1980 | HMPREF0621_0841 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.434 |
| NadR | nudF | HMPREF0621_1980 | HMPREF0621_0364 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.434 |
| arsC2 | dapE | HMPREF0621_0360 | HMPREF0621_0361 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.658 |
| arsC2 | icc | HMPREF0621_0360 | HMPREF0621_0365 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Icc-like protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.469 |
| arsC2 | nudF | HMPREF0621_0360 | HMPREF0621_0364 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.485 |
| arsC2 | psiE | HMPREF0621_0360 | HMPREF0621_0363 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Protein PsiE; COG: COG3223; Pfam: PF06146; InterPro: IPR009315. | 0.524 |
| arsC2 | vanY | HMPREF0621_0360 | HMPREF0621_0362 | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1876; Pfam: PF02557; InterPro: IPR003709. | 0.623 |
| dapE | arsC2 | HMPREF0621_0361 | HMPREF0621_0360 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | 0.658 |
| dapE | nudF | HMPREF0621_0361 | HMPREF0621_0364 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.631 |
| dapE | psiE | HMPREF0621_0361 | HMPREF0621_0363 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Protein PsiE; COG: COG3223; Pfam: PF06146; InterPro: IPR009315. | 0.686 |
| dapE | vanY | HMPREF0621_0361 | HMPREF0621_0362 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | Serine-type D-Ala-D-Ala carboxypeptidase; COG: COG1876; Pfam: PF02557; InterPro: IPR003709. | 0.794 |
| hflD | icc | HMPREF0621_1872 | HMPREF0621_0365 | Hypothetical protein; COG: COG2915; Pfam: PF04356; InterPro: IPR007451. | Icc-like protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.401 |
| hflD | nudF | HMPREF0621_1872 | HMPREF0621_0364 | Hypothetical protein; COG: COG2915; Pfam: PF04356; InterPro: IPR007451. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.445 |
| icc | arsC2 | HMPREF0621_0365 | HMPREF0621_0360 | Icc-like protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Transcriptional regulator, Spx/MgsR family; COG: COG1393; Pfam: PF03960; InterPro: IPR012335; Belongs to the ArsC family. | 0.469 |
| icc | hflD | HMPREF0621_0365 | HMPREF0621_1872 | Icc-like protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Hypothetical protein; COG: COG2915; Pfam: PF04356; InterPro: IPR007451. | 0.401 |
| icc | nudF | HMPREF0621_0365 | HMPREF0621_0364 | Icc-like protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.521 |
| icc | psiE | HMPREF0621_0365 | HMPREF0621_0363 | Icc-like protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | Protein PsiE; COG: COG3223; Pfam: PF06146; InterPro: IPR009315. | 0.408 |
| nudE | NadR | HMPREF0621_0841 | HMPREF0621_1980 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.434 |
| nudE | nudF | HMPREF0621_0841 | HMPREF0621_0364 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.900 |
| nudE | prs | HMPREF0621_0841 | HMPREF0621_1220 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.902 |