| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| exsB | nrdG | HMPREF0621_1758 | HMPREF0621_0412 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.547 |
| exsB | queD | HMPREF0621_1758 | HMPREF0621_1759 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.993 |
| exsB | queF | HMPREF0621_1758 | HMPREF0621_1482 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.987 |
| guaA | nrdG | HMPREF0621_0382 | HMPREF0621_0412 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.440 |
| guaA | queD | HMPREF0621_0382 | HMPREF0621_1759 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.433 |
| guaA | queF | HMPREF0621_0382 | HMPREF0621_1482 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.637 |
| nrdD | nrdG | HMPREF0621_0411 | HMPREF0621_0412 | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477,PF01228; InterPro: IPR012833. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.979 |
| nrdG | exsB | HMPREF0621_0412 | HMPREF0621_1758 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.547 |
| nrdG | guaA | HMPREF0621_0412 | HMPREF0621_0382 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.440 |
| nrdG | nrdD | HMPREF0621_0412 | HMPREF0621_0411 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477,PF01228; InterPro: IPR012833. | 0.979 |
| nrdG | queD | HMPREF0621_0412 | HMPREF0621_1759 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.723 |
| nrdG | queF | HMPREF0621_0412 | HMPREF0621_1482 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.781 |
| queD | exsB | HMPREF0621_1759 | HMPREF0621_1758 | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.993 |
| queD | guaA | HMPREF0621_1759 | HMPREF0621_0382 | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.433 |
| queD | nrdG | HMPREF0621_1759 | HMPREF0621_0412 | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.723 |
| queD | queF | HMPREF0621_1759 | HMPREF0621_1482 | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.802 |
| queF | exsB | HMPREF0621_1482 | HMPREF0621_1758 | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.987 |
| queF | guaA | HMPREF0621_1482 | HMPREF0621_0382 | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.637 |
| queF | nrdG | HMPREF0621_1482 | HMPREF0621_0412 | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.781 |
| queF | queD | HMPREF0621_1482 | HMPREF0621_1759 | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.802 |