| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ssb2 | dnaB | HMPREF0621_0222 | HMPREF0621_1486 | Single-strand binding family protein; COG: COG0629; Pfam: PF00436; InterPro: IPR011344. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.626 |
| Ssb2 | dnaE | HMPREF0621_0222 | HMPREF0621_0451 | Single-strand binding family protein; COG: COG0629; Pfam: PF00436; InterPro: IPR011344. | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | 0.972 |
| Ssb2 | dnaN | HMPREF0621_0222 | HMPREF0621_0117 | Single-strand binding family protein; COG: COG0629; Pfam: PF00436; InterPro: IPR011344. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.432 |
| Ssb2 | dnaX | HMPREF0621_0222 | HMPREF0621_0975 | Single-strand binding family protein; COG: COG0629; Pfam: PF00436; InterPro: IPR011344. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.971 |
| Ssb2 | holC | HMPREF0621_0222 | HMPREF0621_1699 | Single-strand binding family protein; COG: COG0629; Pfam: PF00436; InterPro: IPR011344. | DNA polymerase III subunit chi; COG: COG2927; Pfam: PF04364; InterPro: IPR007459. | 0.961 |
| YijF | dnaE | HMPREF0621_0450 | HMPREF0621_0451 | Hypothetical protein; COG: COG3738; Pfam: PF06940; InterPro: IPR009706. | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | 0.775 |
| dnaB | Ssb2 | HMPREF0621_1486 | HMPREF0621_0222 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | Single-strand binding family protein; COG: COG0629; Pfam: PF00436; InterPro: IPR011344. | 0.626 |
| dnaB | dnaE | HMPREF0621_1486 | HMPREF0621_0451 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | 0.751 |
| dnaB | dnaN | HMPREF0621_1486 | HMPREF0621_0117 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.449 |
| dnaB | dnaX | HMPREF0621_1486 | HMPREF0621_0975 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.724 |
| dnaB | holA | HMPREF0621_1486 | HMPREF0621_0065 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | 0.459 |
| dnaE | Ssb2 | HMPREF0621_0451 | HMPREF0621_0222 | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | Single-strand binding family protein; COG: COG0629; Pfam: PF00436; InterPro: IPR011344. | 0.972 |
| dnaE | YijF | HMPREF0621_0451 | HMPREF0621_0450 | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | Hypothetical protein; COG: COG3738; Pfam: PF06940; InterPro: IPR009706. | 0.775 |
| dnaE | dnaB | HMPREF0621_0451 | HMPREF0621_1486 | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.751 |
| dnaE | dnaN | HMPREF0621_0451 | HMPREF0621_0117 | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.997 |
| dnaE | dnaQ | HMPREF0621_0451 | HMPREF0621_1070 | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. | 0.997 |
| dnaE | dnaX | HMPREF0621_0451 | HMPREF0621_0975 | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.997 |
| dnaE | holA | HMPREF0621_0451 | HMPREF0621_0065 | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144; InterPro: IPR005790. | 0.997 |
| dnaE | holB | HMPREF0621_0451 | HMPREF0621_0594 | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | DNA polymerase III, delta' subunit; COG: COG0470; Pfam: PF09115; InterPro: IPR004622. | 0.997 |
| dnaE | holC | HMPREF0621_0451 | HMPREF0621_1699 | DNA polymerase III subunit alpha; COG: COG0587; Pfam: PF02811,PF07733,PF01336; InterPro: IPR004805. | DNA polymerase III subunit chi; COG: COG2927; Pfam: PF04364; InterPro: IPR007459. | 0.996 |