| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YwrO | kefC | HMPREF0621_1184 | HMPREF0621_0480 | Flavodoxin-like protein; COG: COG2249; Pfam: PF02525; InterPro: IPR003680. | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.881 |
| aad | gloA2 | HMPREF0621_0890 | HMPREF0621_0470 | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Glyoxalase family protein; COG: COG0346; Pfam: PF00903; InterPro: IPR004360. | 0.435 |
| aad | kdsD2 | HMPREF0621_0890 | HMPREF0621_1452 | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Sugar isomerase, KpsF/GutQ family; COG: COG0794; Pfam: PF01380,PF00571; InterPro: IPR004800. | 0.448 |
| aad | kefC | HMPREF0621_0890 | HMPREF0621_0480 | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.483 |
| aad | thrA | HMPREF0621_0890 | HMPREF0621_1055 | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.594 |
| gloA2 | aad | HMPREF0621_0470 | HMPREF0621_0890 | Glyoxalase family protein; COG: COG0346; Pfam: PF00903; InterPro: IPR004360. | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.435 |
| gloA2 | kefC | HMPREF0621_0470 | HMPREF0621_0480 | Glyoxalase family protein; COG: COG0346; Pfam: PF00903; InterPro: IPR004360. | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.505 |
| guaB | kdsD2 | HMPREF0621_0384 | HMPREF0621_1452 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Sugar isomerase, KpsF/GutQ family; COG: COG0794; Pfam: PF01380,PF00571; InterPro: IPR004800. | 0.588 |
| guaB | kefC | HMPREF0621_0384 | HMPREF0621_0480 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.599 |
| guaB | thrA | HMPREF0621_0384 | HMPREF0621_1055 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.424 |
| hup | ihfA | HMPREF0621_0617 | HMPREF0621_1375 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | Integration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.641 |
| hup | kefC | HMPREF0621_0617 | HMPREF0621_0480 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.498 |
| ihfA | hup | HMPREF0621_1375 | HMPREF0621_0617 | Integration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 0.641 |
| ihfA | ihfB | HMPREF0621_1375 | HMPREF0621_0995 | Integration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | Integration host factor, beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.963 |
| ihfA | kefC | HMPREF0621_1375 | HMPREF0621_0480 | Integration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.498 |
| ihfB | ihfA | HMPREF0621_0995 | HMPREF0621_1375 | Integration host factor, beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | Integration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.963 |
| ihfB | kefC | HMPREF0621_0995 | HMPREF0621_0480 | Integration host factor, beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.498 |
| kdsD2 | aad | HMPREF0621_1452 | HMPREF0621_0890 | Sugar isomerase, KpsF/GutQ family; COG: COG0794; Pfam: PF01380,PF00571; InterPro: IPR004800. | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.448 |
| kdsD2 | guaB | HMPREF0621_1452 | HMPREF0621_0384 | Sugar isomerase, KpsF/GutQ family; COG: COG0794; Pfam: PF01380,PF00571; InterPro: IPR004800. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.588 |
| kdsD2 | kefC | HMPREF0621_1452 | HMPREF0621_0480 | Sugar isomerase, KpsF/GutQ family; COG: COG0794; Pfam: PF01380,PF00571; InterPro: IPR004800. | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.565 |