| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX51014.1 | YigP | HMPREF0621_0601 | HMPREF0621_0602 | Hypothetical protein. | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | 0.773 |
| EEX51014.1 | dsbD | HMPREF0621_0601 | HMPREF0621_1049 | Hypothetical protein. | Thioredoxin; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. | 0.449 |
| EEX51014.1 | nhaA | HMPREF0621_0601 | HMPREF0621_0599 | Hypothetical protein. | Na+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. | 0.419 |
| EEX51014.1 | polA | HMPREF0621_0601 | HMPREF0621_0286 | Hypothetical protein. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.400 |
| EEX51014.1 | tatA | HMPREF0621_0601 | HMPREF0621_0604 | Hypothetical protein. | Twin arginine-targeting protein translocase, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.472 |
| EEX51014.1 | tatB | HMPREF0621_0601 | HMPREF0621_0605 | Hypothetical protein. | Twin arginine-targeting protein translocase TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.472 |
| EEX51014.1 | tatC | HMPREF0621_0601 | HMPREF0621_0606 | Hypothetical protein. | Twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.472 |
| EEX51014.1 | ubiB | HMPREF0621_0601 | HMPREF0621_0603 | Hypothetical protein. | 2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | 0.693 |
| EEX51014.1 | ubiE | HMPREF0621_0601 | HMPREF0621_0600 | Hypothetical protein. | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.727 |
| YigP | EEX51014.1 | HMPREF0621_0602 | HMPREF0621_0601 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Hypothetical protein. | 0.773 |
| YigP | dsbD | HMPREF0621_0602 | HMPREF0621_1049 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Thioredoxin; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. | 0.403 |
| YigP | nhaA | HMPREF0621_0602 | HMPREF0621_0599 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Na+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. | 0.419 |
| YigP | tatA | HMPREF0621_0602 | HMPREF0621_0604 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Twin arginine-targeting protein translocase, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.536 |
| YigP | tatB | HMPREF0621_0602 | HMPREF0621_0605 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Twin arginine-targeting protein translocase TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.557 |
| YigP | tatC | HMPREF0621_0602 | HMPREF0621_0606 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.533 |
| YigP | ubiB | HMPREF0621_0602 | HMPREF0621_0603 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | 2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | 0.737 |
| YigP | ubiE | HMPREF0621_0602 | HMPREF0621_0600 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.832 |
| dsbD | EEX51014.1 | HMPREF0621_1049 | HMPREF0621_0601 | Thioredoxin; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. | Hypothetical protein. | 0.449 |
| dsbD | YigP | HMPREF0621_1049 | HMPREF0621_0602 | Thioredoxin; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | 0.403 |
| nhaA | EEX51014.1 | HMPREF0621_0599 | HMPREF0621_0601 | Na+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. | Hypothetical protein. | 0.419 |