| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YigP | hemB | HMPREF0621_0602 | HMPREF0621_0607 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family. | 0.410 |
| YigP | tatA | HMPREF0621_0602 | HMPREF0621_0604 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Twin arginine-targeting protein translocase, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.536 |
| YigP | tatB | HMPREF0621_0602 | HMPREF0621_0605 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Twin arginine-targeting protein translocase TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.557 |
| YigP | tatC | HMPREF0621_0602 | HMPREF0621_0606 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.533 |
| YigP | ubiB | HMPREF0621_0602 | HMPREF0621_0603 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | 2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | 0.737 |
| YigP | ubiE | HMPREF0621_0602 | HMPREF0621_0600 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.832 |
| guaA | tatA | HMPREF0621_0382 | HMPREF0621_0604 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Twin arginine-targeting protein translocase, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.930 |
| guaA | tatB | HMPREF0621_0382 | HMPREF0621_0605 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Twin arginine-targeting protein translocase TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.930 |
| guaA | tatC | HMPREF0621_0382 | HMPREF0621_0606 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.401 |
| hemB | YigP | HMPREF0621_0607 | HMPREF0621_0602 | Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family. | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | 0.410 |
| hemB | tatA | HMPREF0621_0607 | HMPREF0621_0604 | Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family. | Twin arginine-targeting protein translocase, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.604 |
| hemB | tatB | HMPREF0621_0607 | HMPREF0621_0605 | Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family. | Twin arginine-targeting protein translocase TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.591 |
| hemB | tatC | HMPREF0621_0607 | HMPREF0621_0606 | Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family. | Twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.586 |
| hemB | ubiB | HMPREF0621_0607 | HMPREF0621_0603 | Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family. | 2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | 0.455 |
| hemB | ubiE | HMPREF0621_0607 | HMPREF0621_0600 | Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family. | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.426 |
| secD | secE | HMPREF0621_1042 | HMPREF0621_0631 | Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | 0.721 |
| secD | tatA | HMPREF0621_1042 | HMPREF0621_0604 | Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Twin arginine-targeting protein translocase, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.544 |
| secD | tatC | HMPREF0621_1042 | HMPREF0621_0606 | Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Twin arginine-targeting protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.454 |
| secE | secD | HMPREF0621_0631 | HMPREF0621_1042 | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.721 |
| secE | tatA | HMPREF0621_0631 | HMPREF0621_0604 | Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | Twin arginine-targeting protein translocase, TatA/E family; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.489 |