| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RmuC | aroE | HMPREF0621_0731 | HMPREF0621_0727 | RmuC domain protein; COG: COG1322; Pfam: PF02646; InterPro: IPR003798. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.518 |
| RmuC | maf | HMPREF0621_0731 | HMPREF0621_0730 | RmuC domain protein; COG: COG1322; Pfam: PF02646; InterPro: IPR003798. | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.556 |
| RmuC | sua2 | HMPREF0621_0731 | HMPREF0621_0728 | RmuC domain protein; COG: COG1322; Pfam: PF02646; InterPro: IPR003798. | Putative Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.525 |
| RmuC | topA3 | HMPREF0621_0731 | HMPREF0621_0729 | RmuC domain protein; COG: COG1322; Pfam: PF02646; InterPro: IPR003798. | Topoisomerase DNA-binding C4 zinc finger domain protein; COG: COG0551; Pfam: PF01396; InterPro: IPR013498. | 0.516 |
| aroE | RmuC | HMPREF0621_0727 | HMPREF0621_0731 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | RmuC domain protein; COG: COG1322; Pfam: PF02646; InterPro: IPR003798. | 0.518 |
| aroE | maf | HMPREF0621_0727 | HMPREF0621_0730 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.783 |
| aroE | sua2 | HMPREF0621_0727 | HMPREF0621_0728 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Putative Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.841 |
| aroE | topA3 | HMPREF0621_0727 | HMPREF0621_0729 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Topoisomerase DNA-binding C4 zinc finger domain protein; COG: COG0551; Pfam: PF01396; InterPro: IPR013498. | 0.794 |
| maf | RmuC | HMPREF0621_0730 | HMPREF0621_0731 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | RmuC domain protein; COG: COG1322; Pfam: PF02646; InterPro: IPR003798. | 0.556 |
| maf | aroE | HMPREF0621_0730 | HMPREF0621_0727 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.783 |
| maf | sua2 | HMPREF0621_0730 | HMPREF0621_0728 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Putative Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.741 |
| maf | topA3 | HMPREF0621_0730 | HMPREF0621_0729 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Topoisomerase DNA-binding C4 zinc finger domain protein; COG: COG0551; Pfam: PF01396; InterPro: IPR013498. | 0.734 |
| sua | sua2 | HMPREF0621_1325 | HMPREF0621_0728 | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | Putative Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.429 |
| sua2 | RmuC | HMPREF0621_0728 | HMPREF0621_0731 | Putative Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | RmuC domain protein; COG: COG1322; Pfam: PF02646; InterPro: IPR003798. | 0.525 |
| sua2 | aroE | HMPREF0621_0728 | HMPREF0621_0727 | Putative Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.841 |
| sua2 | maf | HMPREF0621_0728 | HMPREF0621_0730 | Putative Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.741 |
| sua2 | sua | HMPREF0621_0728 | HMPREF0621_1325 | Putative Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | Sua5/YciO/YrdC/YwlC family protein; COG: COG0009; Pfam: PF01300; InterPro: IPR004388; Belongs to the SUA5 family. | 0.429 |
| sua2 | topA3 | HMPREF0621_0728 | HMPREF0621_0729 | Putative Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | Topoisomerase DNA-binding C4 zinc finger domain protein; COG: COG0551; Pfam: PF01396; InterPro: IPR013498. | 0.796 |
| topA3 | RmuC | HMPREF0621_0729 | HMPREF0621_0731 | Topoisomerase DNA-binding C4 zinc finger domain protein; COG: COG0551; Pfam: PF01396; InterPro: IPR013498. | RmuC domain protein; COG: COG1322; Pfam: PF02646; InterPro: IPR003798. | 0.516 |
| topA3 | aroE | HMPREF0621_0729 | HMPREF0621_0727 | Topoisomerase DNA-binding C4 zinc finger domain protein; COG: COG0551; Pfam: PF01396; InterPro: IPR013498. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.794 |