| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YchJ | YihY | HMPREF0621_0787 | HMPREF0621_0788 | Hypothetical protein; COG: COG3012; Pfam: PF02810; Belongs to the UPF0225 family. | YihY family protein; COG: COG1295; Pfam: PF03631; InterPro: IPR004664. | 0.793 |
| YchJ | dtd | HMPREF0621_0787 | HMPREF0621_0789 | Hypothetical protein; COG: COG3012; Pfam: PF02810; Belongs to the UPF0225 family. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.793 |
| YchJ | lysE | HMPREF0621_0787 | HMPREF0621_0786 | Hypothetical protein; COG: COG3012; Pfam: PF02810; Belongs to the UPF0225 family. | L-lysine exporter; COG: COG1279; Pfam: PF01810; InterPro: IPR001123. | 0.609 |
| YihY | YchJ | HMPREF0621_0788 | HMPREF0621_0787 | YihY family protein; COG: COG1295; Pfam: PF03631; InterPro: IPR004664. | Hypothetical protein; COG: COG3012; Pfam: PF02810; Belongs to the UPF0225 family. | 0.793 |
| YihY | dtd | HMPREF0621_0788 | HMPREF0621_0789 | YihY family protein; COG: COG1295; Pfam: PF03631; InterPro: IPR004664. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.802 |
| YihY | lysE | HMPREF0621_0788 | HMPREF0621_0786 | YihY family protein; COG: COG1295; Pfam: PF03631; InterPro: IPR004664. | L-lysine exporter; COG: COG1279; Pfam: PF01810; InterPro: IPR001123. | 0.532 |
| YihY | rpe | HMPREF0621_0788 | HMPREF0621_0785 | YihY family protein; COG: COG1295; Pfam: PF03631; InterPro: IPR004664. | Ribulose-phosphate 3-epimerase; COG: COG0036; Pfam: PF00834; InterPro: IPR013785; Belongs to the ribulose-phosphate 3-epimerase family. | 0.409 |
| YihY | trpS | HMPREF0621_0788 | HMPREF0621_0783 | YihY family protein; COG: COG1295; Pfam: PF03631; InterPro: IPR004664. | tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.432 |
| dtd | YchJ | HMPREF0621_0789 | HMPREF0621_0787 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Hypothetical protein; COG: COG3012; Pfam: PF02810; Belongs to the UPF0225 family. | 0.793 |
| dtd | YihY | HMPREF0621_0789 | HMPREF0621_0788 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | YihY family protein; COG: COG1295; Pfam: PF03631; InterPro: IPR004664. | 0.802 |
| dtd | gph | HMPREF0621_0789 | HMPREF0621_0784 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Phosphoglycolate phosphatase, bacterial; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | 0.432 |
| dtd | lysE | HMPREF0621_0789 | HMPREF0621_0786 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | L-lysine exporter; COG: COG1279; Pfam: PF01810; InterPro: IPR001123. | 0.532 |
| dtd | rpe | HMPREF0621_0789 | HMPREF0621_0785 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Ribulose-phosphate 3-epimerase; COG: COG0036; Pfam: PF00834; InterPro: IPR013785; Belongs to the ribulose-phosphate 3-epimerase family. | 0.454 |
| dtd | trpS | HMPREF0621_0789 | HMPREF0621_0783 | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.410 |
| gph | dtd | HMPREF0621_0784 | HMPREF0621_0789 | Phosphoglycolate phosphatase, bacterial; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.432 |
| gph | lysE | HMPREF0621_0784 | HMPREF0621_0786 | Phosphoglycolate phosphatase, bacterial; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | L-lysine exporter; COG: COG1279; Pfam: PF01810; InterPro: IPR001123. | 0.531 |
| gph | rpe | HMPREF0621_0784 | HMPREF0621_0785 | Phosphoglycolate phosphatase, bacterial; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | Ribulose-phosphate 3-epimerase; COG: COG0036; Pfam: PF00834; InterPro: IPR013785; Belongs to the ribulose-phosphate 3-epimerase family. | 0.863 |
| gph | trpS | HMPREF0621_0784 | HMPREF0621_0783 | Phosphoglycolate phosphatase, bacterial; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.826 |
| lysE | YchJ | HMPREF0621_0786 | HMPREF0621_0787 | L-lysine exporter; COG: COG1279; Pfam: PF01810; InterPro: IPR001123. | Hypothetical protein; COG: COG3012; Pfam: PF02810; Belongs to the UPF0225 family. | 0.609 |
| lysE | YihY | HMPREF0621_0786 | HMPREF0621_0788 | L-lysine exporter; COG: COG1279; Pfam: PF01810; InterPro: IPR001123. | YihY family protein; COG: COG1295; Pfam: PF03631; InterPro: IPR004664. | 0.532 |