| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HcpD_2 | ftsB | HMPREF0621_0794 | HMPREF0621_0798 | Sel1 repeat protein; COG: COG0790; Pfam: PF08238; InterPro: IPR011990. | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.776 |
| HcpD_2 | ispD | HMPREF0621_0794 | HMPREF0621_0797 | Sel1 repeat protein; COG: COG0790; Pfam: PF08238; InterPro: IPR011990. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.773 |
| HcpD_2 | ispF | HMPREF0621_0794 | HMPREF0621_0796 | Sel1 repeat protein; COG: COG0790; Pfam: PF08238; InterPro: IPR011990. | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.773 |
| HcpD_2 | truD | HMPREF0621_0794 | HMPREF0621_0795 | Sel1 repeat protein; COG: COG0790; Pfam: PF08238; InterPro: IPR011990. | tRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. | 0.773 |
| PlpE | ftsB | HMPREF0621_2028 | HMPREF0621_0798 | Hypothetical protein. | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.729 |
| PlpE | ftsL | HMPREF0621_2028 | HMPREF0621_0342 | Hypothetical protein. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.844 |
| fstQ | ftsB | HMPREF0621_0352 | HMPREF0621_0798 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.991 |
| fstQ | ftsL | HMPREF0621_0352 | HMPREF0621_0342 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.994 |
| fstQ | mreD | HMPREF0621_0352 | HMPREF0621_0230 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | 0.405 |
| fstQ | smpA | HMPREF0621_0352 | HMPREF0621_0531 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | SmpA / OmlA family protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.630 |
| fstQ | sspB | HMPREF0621_0352 | HMPREF0621_1454 | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | Stringent starvation protein B; COG: COG2969; Pfam: PF04386; InterPro: IPR007481. | 0.619 |
| ftsB | HcpD_2 | HMPREF0621_0798 | HMPREF0621_0794 | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Sel1 repeat protein; COG: COG0790; Pfam: PF08238; InterPro: IPR011990. | 0.776 |
| ftsB | PlpE | HMPREF0621_0798 | HMPREF0621_2028 | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Hypothetical protein. | 0.729 |
| ftsB | fstQ | HMPREF0621_0798 | HMPREF0621_0352 | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.991 |
| ftsB | ftsL | HMPREF0621_0798 | HMPREF0621_0342 | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.973 |
| ftsB | ispD | HMPREF0621_0798 | HMPREF0621_0797 | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.794 |
| ftsB | ispF | HMPREF0621_0798 | HMPREF0621_0796 | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.794 |
| ftsB | mreD | HMPREF0621_0798 | HMPREF0621_0230 | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | 0.625 |
| ftsB | smpA | HMPREF0621_0798 | HMPREF0621_0531 | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | SmpA / OmlA family protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.736 |
| ftsB | sspB | HMPREF0621_0798 | HMPREF0621_1454 | Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Stringent starvation protein B; COG: COG2969; Pfam: PF04386; InterPro: IPR007481. | 0.738 |