| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX49394.1 | tyrP2 | HMPREF0621_2030 | HMPREF0621_0807 | Tetratricopeptide repeat protein; Pfam: PF04575; InterPro: IPR007655. | Putative toxin-antitoxin system toxin component, PIN family; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.485 |
| frdC | menC | HMPREF0621_1745 | HMPREF0621_1833 | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.714 |
| frdC | tex | HMPREF0621_1745 | HMPREF0621_0895 | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | ASCH domain protein; COG: COG3097; Pfam: PF06164; InterPro: IPR008314; Belongs to the UPF0267 family. | 0.675 |
| frdC | tyrP2 | HMPREF0621_1745 | HMPREF0621_0807 | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | Putative toxin-antitoxin system toxin component, PIN family; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.431 |
| frdC | yfbU | HMPREF0621_1745 | HMPREF0621_2044 | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | YfbU domain protein; COG: COG3013; Pfam: PF03887; InterPro: IPR005587; Belongs to the UPF0304 family. | 0.580 |
| malT | tyrP2 | HMPREF0621_0806 | HMPREF0621_0807 | Transcriptional regulator, LuxR family; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box. | Putative toxin-antitoxin system toxin component, PIN family; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.586 |
| malT | yfbU | HMPREF0621_0806 | HMPREF0621_2044 | Transcriptional regulator, LuxR family; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box. | YfbU domain protein; COG: COG3013; Pfam: PF03887; InterPro: IPR005587; Belongs to the UPF0304 family. | 0.466 |
| menC | frdC | HMPREF0621_1833 | HMPREF0621_1745 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.714 |
| menC | tex | HMPREF0621_1833 | HMPREF0621_0895 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | ASCH domain protein; COG: COG3097; Pfam: PF06164; InterPro: IPR008314; Belongs to the UPF0267 family. | 0.698 |
| menC | tyrP2 | HMPREF0621_1833 | HMPREF0621_0807 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Putative toxin-antitoxin system toxin component, PIN family; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.529 |
| menC | yfbU | HMPREF0621_1833 | HMPREF0621_2044 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | YfbU domain protein; COG: COG3013; Pfam: PF03887; InterPro: IPR005587; Belongs to the UPF0304 family. | 0.691 |
| rhaT2 | rhaT3 | HMPREF0621_0324 | HMPREF0621_0325 | Putative membrane protein; COG: COG0697; Pfam: PF00892; InterPro: IPR000620. | Putative membrane protein; COG: COG0697; Pfam: PF00892; InterPro: IPR000620. | 0.783 |
| rhaT2 | tyrP2 | HMPREF0621_0324 | HMPREF0621_0807 | Putative membrane protein; COG: COG0697; Pfam: PF00892; InterPro: IPR000620. | Putative toxin-antitoxin system toxin component, PIN family; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.474 |
| rhaT3 | rhaT2 | HMPREF0621_0325 | HMPREF0621_0324 | Putative membrane protein; COG: COG0697; Pfam: PF00892; InterPro: IPR000620. | Putative membrane protein; COG: COG0697; Pfam: PF00892; InterPro: IPR000620. | 0.783 |
| rhaT3 | tyrP2 | HMPREF0621_0325 | HMPREF0621_0807 | Putative membrane protein; COG: COG0697; Pfam: PF00892; InterPro: IPR000620. | Putative toxin-antitoxin system toxin component, PIN family; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.449 |
| rpoH | tyrP2 | HMPREF0621_0808 | HMPREF0621_0807 | Alternative sigma factor RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. | Putative toxin-antitoxin system toxin component, PIN family; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.471 |
| tex | frdC | HMPREF0621_0895 | HMPREF0621_1745 | ASCH domain protein; COG: COG3097; Pfam: PF06164; InterPro: IPR008314; Belongs to the UPF0267 family. | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. | 0.675 |
| tex | menC | HMPREF0621_0895 | HMPREF0621_1833 | ASCH domain protein; COG: COG3097; Pfam: PF06164; InterPro: IPR008314; Belongs to the UPF0267 family. | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.698 |
| tex | tyrP2 | HMPREF0621_0895 | HMPREF0621_0807 | ASCH domain protein; COG: COG3097; Pfam: PF06164; InterPro: IPR008314; Belongs to the UPF0267 family. | Putative toxin-antitoxin system toxin component, PIN family; COG: COG0814; Pfam: PF03222; InterPro: IPR002091. | 0.603 |
| tex | yfbU | HMPREF0621_0895 | HMPREF0621_2044 | ASCH domain protein; COG: COG3097; Pfam: PF06164; InterPro: IPR008314; Belongs to the UPF0267 family. | YfbU domain protein; COG: COG3013; Pfam: PF03887; InterPro: IPR005587; Belongs to the UPF0304 family. | 0.708 |