STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yrfGHAD hydrolase, family IA, variant 3; COG: COG1011; Pfam: PF00702; InterPro: IPR005834. (218 aa)    
Predicted Functional Partners:
icc
Icc-like protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
 
  
  0.912
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
    
  0.912
yjjG
HAD hydrolase, TIGR02254 family; COG: COG1011; Pfam: PF00702; InterPro: IPR011951.
     
 0.912
NadR
Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417.
    
 0.912
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.907
YfbR
HD domain protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates.
     
 0.905
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
  0.904
udk
Uridine kinase; COG: COG0572; Pfam: PF00485; InterPro: IPR000764.
  
 
  0.903
surE
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.903
pncB
Nicotinate phosphoribosyltransferase, (NAPRTase) family; COG: COG1488; Pfam: PF04095; InterPro: IPR015977; Belongs to the NAPRTase family.
   
 
 0.903
Your Current Organism:
Pasteurella dagmatis
NCBI taxonomy Id: 667128
Other names: P. dagmatis ATCC 43325, Pasteurella dagmatis ATCC 43325, Pasteurella dagmatis str. ATCC 43325, Pasteurella dagmatis strain ATCC 43325
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