| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX50616.1 | cysQ | HMPREF0621_0842 | HMPREF0621_0843 | Oligopeptide transporter, OPT family; COG: COG1297; Pfam: PF03169; InterPro: IPR004813. | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. | 0.465 |
| EEX50616.1 | nudE | HMPREF0621_0842 | HMPREF0621_0841 | Oligopeptide transporter, OPT family; COG: COG1297; Pfam: PF03169; InterPro: IPR004813. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.475 |
| NadR | nudE | HMPREF0621_1980 | HMPREF0621_0841 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.434 |
| NadR | nudF | HMPREF0621_1980 | HMPREF0621_0364 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.434 |
| NadR | yrfG | HMPREF0621_1980 | HMPREF0621_0840 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | HAD hydrolase, family IA, variant 3; COG: COG1011; Pfam: PF00702; InterPro: IPR005834. | 0.912 |
| cysQ | EEX50616.1 | HMPREF0621_0843 | HMPREF0621_0842 | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. | Oligopeptide transporter, OPT family; COG: COG1297; Pfam: PF03169; InterPro: IPR004813. | 0.465 |
| cysQ | nudE | HMPREF0621_0843 | HMPREF0621_0841 | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.433 |
| hslO | hslR | HMPREF0621_0838 | HMPREF0621_0839 | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | 0.864 |
| hslO | nudE | HMPREF0621_0838 | HMPREF0621_0841 | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.417 |
| hslO | yrfG | HMPREF0621_0838 | HMPREF0621_0840 | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | HAD hydrolase, family IA, variant 3; COG: COG1011; Pfam: PF00702; InterPro: IPR005834. | 0.542 |
| hslR | hslO | HMPREF0621_0839 | HMPREF0621_0838 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.864 |
| hslR | nudE | HMPREF0621_0839 | HMPREF0621_0841 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.567 |
| hslR | yrfG | HMPREF0621_0839 | HMPREF0621_0840 | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | HAD hydrolase, family IA, variant 3; COG: COG1011; Pfam: PF00702; InterPro: IPR005834. | 0.875 |
| nudE | EEX50616.1 | HMPREF0621_0841 | HMPREF0621_0842 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Oligopeptide transporter, OPT family; COG: COG1297; Pfam: PF03169; InterPro: IPR004813. | 0.475 |
| nudE | NadR | HMPREF0621_0841 | HMPREF0621_1980 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.434 |
| nudE | cysQ | HMPREF0621_0841 | HMPREF0621_0843 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. | 0.433 |
| nudE | hslO | HMPREF0621_0841 | HMPREF0621_0838 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.417 |
| nudE | hslR | HMPREF0621_0841 | HMPREF0621_0839 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | S4 domain protein; COG: COG1188; Pfam: PF01479; InterPro: IPR002942; Belongs to the HSP15 family. | 0.567 |
| nudE | nudF | HMPREF0621_0841 | HMPREF0621_0364 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Nudix-type nucleoside diphosphatase, YffH/AdpP family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | 0.900 |
| nudE | prs | HMPREF0621_0841 | HMPREF0621_1220 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.902 |