| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX50656.1 | IlvM | HMPREF0621_0882 | HMPREF0621_0776 | Hypothetical protein; InterPro: IPR001544. | Hypothetical protein; COG: COG3978; 2.2.1.6. | 0.478 |
| EEX50656.1 | folP | HMPREF0621_0882 | HMPREF0621_1272 | Hypothetical protein; InterPro: IPR001544. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.919 |
| EEX50656.1 | hisE | HMPREF0621_0882 | HMPREF0621_0076 | Hypothetical protein; InterPro: IPR001544. | phosphoribosyl-ATP diphosphatase; COG: COG0139; Pfam: PF01502,PF01503; InterPro: IPR008179; In the N-terminal section; belongs to the PRA-CH family. | 0.542 |
| EEX50656.1 | ilvB | HMPREF0621_0882 | HMPREF0621_0775 | Hypothetical protein; InterPro: IPR001544. | Acetolactate synthase, large subunit, biosynthetic type; COG: COG0028; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012846. | 0.476 |
| EEX50656.1 | ilvD | HMPREF0621_0882 | HMPREF0621_0779 | Hypothetical protein; InterPro: IPR001544. | Dihydroxy-acid dehydratase; COG: COG0129; Pfam: PF00920; InterPro: IPR004404; Belongs to the IlvD/Edd family. | 0.739 |
| EEX50656.1 | leuA | HMPREF0621_0882 | HMPREF0621_0234 | Hypothetical protein; InterPro: IPR001544. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.705 |
| EEX50656.1 | pabB | HMPREF0621_0882 | HMPREF0621_0883 | Hypothetical protein; InterPro: IPR001544. | Chorismate binding enzyme; COG: COG0147; Pfam: PF00425; InterPro: IPR005801. | 0.995 |
| EEX50656.1 | tdcF | HMPREF0621_0882 | HMPREF0621_0881 | Hypothetical protein; InterPro: IPR001544. | Putative endoribonuclease L-PSP; COG: COG0251; Pfam: PF01042; InterPro: IPR013813. | 0.610 |
| EEX50656.1 | thrA | HMPREF0621_0882 | HMPREF0621_1055 | Hypothetical protein; InterPro: IPR001544. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.679 |
| EEX50656.1 | trpG2 | HMPREF0621_0882 | HMPREF0621_0884 | Hypothetical protein; InterPro: IPR001544. | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | 0.964 |
| IlvM | EEX50656.1 | HMPREF0621_0776 | HMPREF0621_0882 | Hypothetical protein; COG: COG3978; 2.2.1.6. | Hypothetical protein; InterPro: IPR001544. | 0.478 |
| IlvM | ilvB | HMPREF0621_0776 | HMPREF0621_0775 | Hypothetical protein; COG: COG3978; 2.2.1.6. | Acetolactate synthase, large subunit, biosynthetic type; COG: COG0028; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012846. | 0.970 |
| IlvM | ilvD | HMPREF0621_0776 | HMPREF0621_0779 | Hypothetical protein; COG: COG3978; 2.2.1.6. | Dihydroxy-acid dehydratase; COG: COG0129; Pfam: PF00920; InterPro: IPR004404; Belongs to the IlvD/Edd family. | 0.862 |
| IlvM | leuA | HMPREF0621_0776 | HMPREF0621_0234 | Hypothetical protein; COG: COG3978; 2.2.1.6. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.820 |
| folP | EEX50656.1 | HMPREF0621_1272 | HMPREF0621_0882 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Hypothetical protein; InterPro: IPR001544. | 0.919 |
| folP | thrA | HMPREF0621_1272 | HMPREF0621_1055 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.429 |
| folP | trpG2 | HMPREF0621_1272 | HMPREF0621_0884 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | 0.469 |
| hisE | EEX50656.1 | HMPREF0621_0076 | HMPREF0621_0882 | phosphoribosyl-ATP diphosphatase; COG: COG0139; Pfam: PF01502,PF01503; InterPro: IPR008179; In the N-terminal section; belongs to the PRA-CH family. | Hypothetical protein; InterPro: IPR001544. | 0.542 |
| hisE | ilvD | HMPREF0621_0076 | HMPREF0621_0779 | phosphoribosyl-ATP diphosphatase; COG: COG0139; Pfam: PF01502,PF01503; InterPro: IPR008179; In the N-terminal section; belongs to the PRA-CH family. | Dihydroxy-acid dehydratase; COG: COG0129; Pfam: PF00920; InterPro: IPR004404; Belongs to the IlvD/Edd family. | 0.542 |
| hisE | leuA | HMPREF0621_0076 | HMPREF0621_0234 | phosphoribosyl-ATP diphosphatase; COG: COG0139; Pfam: PF01502,PF01503; InterPro: IPR008179; In the N-terminal section; belongs to the PRA-CH family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.518 |