| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX49631.1 | dnaJ | HMPREF0621_1678 | HMPREF0621_0949 | FAD linked oxidase, C-terminal domain protein; COG: COG0277; Pfam: PF01565,PF02913,PF00037; InterPro: IPR004113. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.422 |
| EEX49631.1 | glpA | HMPREF0621_1678 | HMPREF0621_0905 | FAD linked oxidase, C-terminal domain protein; COG: COG0277; Pfam: PF01565,PF02913,PF00037; InterPro: IPR004113. | Glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; COG: COG0578; Pfam: PF01266,PF04324; InterPro: IPR006076; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.547 |
| EEX49631.1 | glpF | HMPREF0621_1678 | HMPREF0621_0901 | FAD linked oxidase, C-terminal domain protein; COG: COG0277; Pfam: PF01565,PF02913,PF00037; InterPro: IPR004113. | MIP family channel protein; COG: COG0580; Pfam: PF00230; InterPro: IPR000425; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.445 |
| EEX49631.1 | glpK | HMPREF0621_1678 | HMPREF0621_0900 | FAD linked oxidase, C-terminal domain protein; COG: COG0277; Pfam: PF01565,PF02913,PF00037; InterPro: IPR004113. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.473 |
| EEX49631.1 | maeB | HMPREF0621_1678 | HMPREF0621_0489 | FAD linked oxidase, C-terminal domain protein; COG: COG0277; Pfam: PF01565,PF02913,PF00037; InterPro: IPR004113. | Phosphate acetyl/butyryl transferase; COG: COG0281; Pfam: PF00390,PF03949,PF01515; InterPro: IPR002505. | 0.670 |
| Stp | dnaJ | HMPREF0621_1555 | HMPREF0621_0949 | Hypothetical protein; Pfam: PF07228; InterPro: IPR001932. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.551 |
| Stp | glpF | HMPREF0621_1555 | HMPREF0621_0901 | Hypothetical protein; Pfam: PF07228; InterPro: IPR001932. | MIP family channel protein; COG: COG0580; Pfam: PF00230; InterPro: IPR000425; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.610 |
| Stp | ndk | HMPREF0621_1555 | HMPREF0621_1802 | Hypothetical protein; Pfam: PF07228; InterPro: IPR001932. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.415 |
| dnaJ | EEX49631.1 | HMPREF0621_0949 | HMPREF0621_1678 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | FAD linked oxidase, C-terminal domain protein; COG: COG0277; Pfam: PF01565,PF02913,PF00037; InterPro: IPR004113. | 0.422 |
| dnaJ | Stp | HMPREF0621_0949 | HMPREF0621_1555 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Hypothetical protein; Pfam: PF07228; InterPro: IPR001932. | 0.551 |
| dnaJ | glpF | HMPREF0621_0949 | HMPREF0621_0901 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | MIP family channel protein; COG: COG0580; Pfam: PF00230; InterPro: IPR000425; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.608 |
| dnaJ | maeB | HMPREF0621_0949 | HMPREF0621_0489 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Phosphate acetyl/butyryl transferase; COG: COG0281; Pfam: PF00390,PF03949,PF01515; InterPro: IPR002505. | 0.521 |
| dnaJ | ndk | HMPREF0621_0949 | HMPREF0621_1802 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.711 |
| glpA | EEX49631.1 | HMPREF0621_0905 | HMPREF0621_1678 | Glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; COG: COG0578; Pfam: PF01266,PF04324; InterPro: IPR006076; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | FAD linked oxidase, C-terminal domain protein; COG: COG0277; Pfam: PF01565,PF02913,PF00037; InterPro: IPR004113. | 0.547 |
| glpA | glpB | HMPREF0621_0905 | HMPREF0621_0906 | Glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; COG: COG0578; Pfam: PF01266,PF04324; InterPro: IPR006076; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | Glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. | 0.997 |
| glpA | glpF | HMPREF0621_0905 | HMPREF0621_0901 | Glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; COG: COG0578; Pfam: PF01266,PF04324; InterPro: IPR006076; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | MIP family channel protein; COG: COG0580; Pfam: PF00230; InterPro: IPR000425; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.868 |
| glpA | glpK | HMPREF0621_0905 | HMPREF0621_0900 | Glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; COG: COG0578; Pfam: PF01266,PF04324; InterPro: IPR006076; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.987 |
| glpA | glpQ | HMPREF0621_0905 | HMPREF0621_0902 | Glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; COG: COG0578; Pfam: PF01266,PF04324; InterPro: IPR006076; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | Glycerophosphodiester phosphodiesterase; COG: COG0584; Pfam: PF03009; InterPro: IPR004129. | 0.829 |
| glpA | glpT | HMPREF0621_0905 | HMPREF0621_0904 | Glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; COG: COG0578; Pfam: PF01266,PF04324; InterPro: IPR006076; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | Glycerol-3-phosphate transporter; COG: COG2271; Pfam: PF07690; InterPro: IPR005267. | 0.589 |
| glpB | glpA | HMPREF0621_0906 | HMPREF0621_0905 | Glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. | Glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; COG: COG0578; Pfam: PF01266,PF04324; InterPro: IPR006076; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.997 |