| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Wza | cap5G | HMPREF0621_0368 | HMPREF0621_0375 | Polysaccharide biosynthesis/export protein; COG: COG1596; Pfam: PF02563; InterPro: IPR003715. | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | 0.499 |
| Wza | wcgV | HMPREF0621_0368 | HMPREF0621_0374 | Polysaccharide biosynthesis/export protein; COG: COG1596; Pfam: PF02563; InterPro: IPR003715. | Glycosyltransferase, group 1 family protein; COG: COG0438; Pfam: PF00534; InterPro: IPR001296. | 0.642 |
| Wza | wecA | HMPREF0621_0368 | HMPREF0621_0934 | Polysaccharide biosynthesis/export protein; COG: COG1596; Pfam: PF02563; InterPro: IPR003715. | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily. | 0.543 |
| YijE | hemL | HMPREF0621_0936 | HMPREF0621_0935 | Putative membrane protein; Pfam: PF00892; InterPro: IPR000620. | Glutamate-1-semialdehyde-2,1-aminomutase; COG: COG0001; Pfam: PF00202; InterPro: IPR004639. | 0.777 |
| YijE | wecA | HMPREF0621_0936 | HMPREF0621_0934 | Putative membrane protein; Pfam: PF00892; InterPro: IPR000620. | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily. | 0.553 |
| YijE | wzzE | HMPREF0621_0936 | HMPREF0621_0933 | Putative membrane protein; Pfam: PF00892; InterPro: IPR000620. | Putative lipopolysaccharide biosynthesis protein WzzE. | 0.483 |
| cap5G | Wza | HMPREF0621_0375 | HMPREF0621_0368 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Polysaccharide biosynthesis/export protein; COG: COG1596; Pfam: PF02563; InterPro: IPR003715. | 0.499 |
| cap5G | wcgV | HMPREF0621_0375 | HMPREF0621_0374 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Glycosyltransferase, group 1 family protein; COG: COG0438; Pfam: PF00534; InterPro: IPR001296. | 0.976 |
| cap5G | wecA | HMPREF0621_0375 | HMPREF0621_0934 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily. | 0.760 |
| cap5G | wzzE | HMPREF0621_0375 | HMPREF0621_0933 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Putative lipopolysaccharide biosynthesis protein WzzE. | 0.568 |
| hemL | YijE | HMPREF0621_0935 | HMPREF0621_0936 | Glutamate-1-semialdehyde-2,1-aminomutase; COG: COG0001; Pfam: PF00202; InterPro: IPR004639. | Putative membrane protein; Pfam: PF00892; InterPro: IPR000620. | 0.777 |
| hemL | wecA | HMPREF0621_0935 | HMPREF0621_0934 | Glutamate-1-semialdehyde-2,1-aminomutase; COG: COG0001; Pfam: PF00202; InterPro: IPR004639. | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily. | 0.550 |
| hemL | wzzE | HMPREF0621_0935 | HMPREF0621_0933 | Glutamate-1-semialdehyde-2,1-aminomutase; COG: COG0001; Pfam: PF00202; InterPro: IPR004639. | Putative lipopolysaccharide biosynthesis protein WzzE. | 0.492 |
| murD | murE | HMPREF0621_0347 | HMPREF0621_0344 | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.993 |
| murD | murF | HMPREF0621_0347 | HMPREF0621_0345 | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.971 |
| murD | murG | HMPREF0621_0347 | HMPREF0621_0349 | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.990 |
| murD | wecA | HMPREF0621_0347 | HMPREF0621_0934 | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily. | 0.682 |
| murE | murD | HMPREF0621_0344 | HMPREF0621_0347 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.993 |
| murE | murF | HMPREF0621_0344 | HMPREF0621_0345 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.999 |
| murE | murG | HMPREF0621_0344 | HMPREF0621_0349 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.943 |