STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmbRTonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR010949. (778 aa)    
Predicted Functional Partners:
tonB2
TonB-dependent receptor; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 0.677
TdhA
TonB-dependent siderophore receptor; Pfam: PF07715,PF00593; InterPro: IPR010105.
  
     0.619
EEX49801.1
Hypothetical protein; COG: COG3721; Pfam: PF06228; InterPro: IPR010413.
 
    0.521
HasR_1
TonB-dependent receptor; Pfam: PF07715,PF00593; InterPro: IPR000531.
  
    0.505
Hsf2_4
Putative phage prohead protease, HK97 family; COG: COG5295; Pfam: PF05658,PF05662,PF03895; InterPro: IPR005594.
  
     0.474
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
       0.474
EEX51396.1
Outer membrane autotransporter barrel domain protein; Pfam: PF03797; InterPro: IPR006315.
  
 
 
 0.468
Cya_1
Type I secretion target GGXGXDXXX repeat (2 copies); Pfam: PF00353.
    
 
 0.463
EEX49772.1
TonB-dependent receptor; COG: COG1629; Pfam: PF07715,PF00593; InterPro: IPR000531.
  
     0.461
EEX50193.1
Putative membrane-bound metal-dependent hydrolase; Pfam: PF04307; InterPro: IPR007404.
  
     0.449
Your Current Organism:
Pasteurella dagmatis
NCBI taxonomy Id: 667128
Other names: P. dagmatis ATCC 43325, Pasteurella dagmatis ATCC 43325, Pasteurella dagmatis str. ATCC 43325, Pasteurella dagmatis strain ATCC 43325
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