| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cutC | nagB | HMPREF0621_1451 | HMPREF0621_0952 | CutC family protein; Participates in the control of copper homeostasis. Belongs to the CutC family. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.495 |
| glmM | glmS | HMPREF0621_1273 | HMPREF0621_0616 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.950 |
| glmM | nagA | HMPREF0621_1273 | HMPREF0621_0951 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | N-acetylglucosamine-6-phosphate deacetylase; COG: COG1820; Pfam: PF01979; InterPro: IPR003764. | 0.904 |
| glmM | nagB | HMPREF0621_1273 | HMPREF0621_0952 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.904 |
| glmS | glmM | HMPREF0621_0616 | HMPREF0621_1273 | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.950 |
| glmS | manA | HMPREF0621_0616 | HMPREF0621_1713 | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Mannose-6-phosphate isomerase, class I; COG: COG1482; Pfam: PF01238; InterPro: IPR001250. | 0.912 |
| glmS | nagA | HMPREF0621_0616 | HMPREF0621_0951 | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | N-acetylglucosamine-6-phosphate deacetylase; COG: COG1820; Pfam: PF01979; InterPro: IPR003764. | 0.934 |
| glmS | nagB | HMPREF0621_0616 | HMPREF0621_0952 | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.915 |
| glmS | nagC2 | HMPREF0621_0616 | HMPREF0621_1960 | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR000600. | 0.903 |
| glmS | pgi | HMPREF0621_0616 | HMPREF0621_1484 | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Glucose-6-phosphate isomerase; COG: COG0166; Pfam: PF00342; InterPro: IPR001672; Belongs to the GPI family. | 0.930 |
| glmS | scrK | HMPREF0621_0616 | HMPREF0621_1873 | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294; InterPro: IPR011611; Belongs to the carbohydrate kinase PfkB family. | 0.904 |
| manA | glmS | HMPREF0621_1713 | HMPREF0621_0616 | Mannose-6-phosphate isomerase, class I; COG: COG1482; Pfam: PF01238; InterPro: IPR001250. | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.912 |
| manA | nagB | HMPREF0621_1713 | HMPREF0621_0952 | Mannose-6-phosphate isomerase, class I; COG: COG1482; Pfam: PF01238; InterPro: IPR001250. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.909 |
| manA | nagC2 | HMPREF0621_1713 | HMPREF0621_1960 | Mannose-6-phosphate isomerase, class I; COG: COG1482; Pfam: PF01238; InterPro: IPR001250. | ROK family protein; COG: COG1940; Pfam: PF00480; InterPro: IPR000600. | 0.906 |
| manA | pgi | HMPREF0621_1713 | HMPREF0621_1484 | Mannose-6-phosphate isomerase, class I; COG: COG1482; Pfam: PF01238; InterPro: IPR001250. | Glucose-6-phosphate isomerase; COG: COG0166; Pfam: PF00342; InterPro: IPR001672; Belongs to the GPI family. | 0.943 |
| manA | scrK | HMPREF0621_1713 | HMPREF0621_1873 | Mannose-6-phosphate isomerase, class I; COG: COG1482; Pfam: PF01238; InterPro: IPR001250. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294; InterPro: IPR011611; Belongs to the carbohydrate kinase PfkB family. | 0.905 |
| nagA | glmM | HMPREF0621_0951 | HMPREF0621_1273 | N-acetylglucosamine-6-phosphate deacetylase; COG: COG1820; Pfam: PF01979; InterPro: IPR003764. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.904 |
| nagA | glmS | HMPREF0621_0951 | HMPREF0621_0616 | N-acetylglucosamine-6-phosphate deacetylase; COG: COG1820; Pfam: PF01979; InterPro: IPR003764. | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.934 |
| nagA | nagB | HMPREF0621_0951 | HMPREF0621_0952 | N-acetylglucosamine-6-phosphate deacetylase; COG: COG1820; Pfam: PF01979; InterPro: IPR003764. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.999 |
| nagA | nagE | HMPREF0621_0951 | HMPREF0621_0953 | N-acetylglucosamine-6-phosphate deacetylase; COG: COG1820; Pfam: PF01979; InterPro: IPR003764. | PTS system, N-acetylglucosamine-specific IIBC component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR010974. | 0.967 |