STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)    
Predicted Functional Partners:
hypB
Hydrogenase accessory protein HypB; COG: COG0378; Pfam: PF02492; InterPro: IPR004392.
 
 
 0.894
hypD
Hydrogenase expression/formation protein HypD; COG: COG0409; Pfam: PF01924; InterPro: IPR002780; Belongs to the HypD family.
 
  
 0.849
hypE
Hydrogenase expression/formation protein HypE; COG: COG0309; Pfam: PF00586,PF02769; InterPro: IPR011854.
 
  
 0.843
hypF
Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.823
hypC
Hydrogenase assembly chaperone HypC/HupF; COG: COG0298; Pfam: PF01455; InterPro: IPR001109.
 
  
 0.813
hyfG
Respiratory-chain NADH dehydrogenase, 30 Kd subunit; COG: COG3261; Pfam: PF00329,PF00374,PF00346; InterPro: IPR001135.
  
 
 0.712
ureG
Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
  
 
 0.554
wzs
Chain length determinant protein; COG: COG3206; Pfam: PF02706; InterPro: IPR003856.
   
   0.526
mrp
CobQ/CobB/MinD/ParA nucleotide binding domain protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
   0.526
hyfA
4Fe-4S binding domain protein; COG: COG1142; Pfam: PF00037.
  
  
 0.516
Your Current Organism:
Pasteurella dagmatis
NCBI taxonomy Id: 667128
Other names: P. dagmatis ATCC 43325, Pasteurella dagmatis ATCC 43325, Pasteurella dagmatis str. ATCC 43325, Pasteurella dagmatis strain ATCC 43325
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