| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX50473.1 | ampD | HMPREF0621_1096 | HMPREF0621_1097 | Hypothetical protein. | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | 0.773 |
| EEX50473.1 | coaE | HMPREF0621_1096 | HMPREF0621_1091 | Hypothetical protein. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.400 |
| EEX50473.1 | pilA | HMPREF0621_1096 | HMPREF0621_1095 | Hypothetical protein. | Prepilin-type cleavage/methylation N-terminal domain protein; COG: COG4969; Pfam: PF07963; InterPro: IPR001082; Belongs to the N-Me-Phe pilin family. | 0.556 |
| EEX50473.1 | pilB | HMPREF0621_1096 | HMPREF0621_1094 | Hypothetical protein. | Type II/IV secretion system protein; COG: COG2804; Pfam: PF05157,PF00437; InterPro: IPR001482. | 0.556 |
| EEX50473.1 | pilC | HMPREF0621_1096 | HMPREF0621_1093 | Hypothetical protein. | Bacterial type II secretion system domain protein F; Pfam: PF00482; InterPro: IPR001992. | 0.556 |
| EEX50473.1 | pilD | HMPREF0621_1096 | HMPREF0621_1092 | Hypothetical protein. | Peptidase, A24 family; Pfam: PF01478; InterPro: IPR000045. | 0.556 |
| EEX50473.1 | yacG | HMPREF0621_1096 | HMPREF0621_1090 | Hypothetical protein. | Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.400 |
| ampD | EEX50473.1 | HMPREF0621_1097 | HMPREF0621_1096 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | Hypothetical protein. | 0.773 |
| ampD | anmK | HMPREF0621_1097 | HMPREF0621_1890 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.491 |
| ampD | coaE | HMPREF0621_1097 | HMPREF0621_1091 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.454 |
| ampD | mpl | HMPREF0621_1097 | HMPREF0621_0400 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. | 0.466 |
| ampD | nagZ | HMPREF0621_1097 | HMPREF0621_1109 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.497 |
| ampD | pilA | HMPREF0621_1097 | HMPREF0621_1095 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | Prepilin-type cleavage/methylation N-terminal domain protein; COG: COG4969; Pfam: PF07963; InterPro: IPR001082; Belongs to the N-Me-Phe pilin family. | 0.596 |
| ampD | pilB | HMPREF0621_1097 | HMPREF0621_1094 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | Type II/IV secretion system protein; COG: COG2804; Pfam: PF05157,PF00437; InterPro: IPR001482. | 0.589 |
| ampD | pilC | HMPREF0621_1097 | HMPREF0621_1093 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | Bacterial type II secretion system domain protein F; Pfam: PF00482; InterPro: IPR001992. | 0.615 |
| ampD | pilD | HMPREF0621_1097 | HMPREF0621_1092 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | Peptidase, A24 family; Pfam: PF01478; InterPro: IPR000045. | 0.610 |
| ampD | yacG | HMPREF0621_1097 | HMPREF0621_1090 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.451 |
| anmK | ampD | HMPREF0621_1890 | HMPREF0621_1097 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | 0.491 |
| anmK | nagZ | HMPREF0621_1890 | HMPREF0621_1109 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.820 |
| coaE | EEX50473.1 | HMPREF0621_1091 | HMPREF0621_1096 | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Hypothetical protein. | 0.400 |