| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| deaD | yfhD | HMPREF0621_1136 | HMPREF0621_1135 | DEAD/DEAH box helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | 0.527 |
| hemY | rseB | HMPREF0621_1895 | HMPREF0621_1924 | hemY protein; COG: COG3071; Pfam: PF07219; InterPro: IPR005254. | MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588. | 0.550 |
| hemY | yfhD | HMPREF0621_1895 | HMPREF0621_1135 | hemY protein; COG: COG3071; Pfam: PF07219; InterPro: IPR005254. | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | 0.429 |
| mutT | yfhD | HMPREF0621_0801 | HMPREF0621_1135 | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | 0.548 |
| plsB | yfhD | HMPREF0621_0098 | HMPREF0621_1135 | Glycerol-3-phosphate O-acyltransferase; COG: COG2937; Pfam: PF01553; InterPro: IPR002123; Belongs to the GPAT/DAPAT family. | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | 0.409 |
| purL | yfhD | HMPREF0621_1824 | HMPREF0621_1135 | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | 0.514 |
| rseB | hemY | HMPREF0621_1924 | HMPREF0621_1895 | MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588. | hemY protein; COG: COG3071; Pfam: PF07219; InterPro: IPR005254. | 0.550 |
| rseB | smtA | HMPREF0621_1924 | HMPREF0621_1630 | MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588. | Methyltransferase domain protein; COG: COG0500; Pfam: PF08241. | 0.727 |
| rseB | yfhD | HMPREF0621_1924 | HMPREF0621_1135 | MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588. | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | 0.566 |
| smtA | rseB | HMPREF0621_1630 | HMPREF0621_1924 | Methyltransferase domain protein; COG: COG0500; Pfam: PF08241. | MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588. | 0.727 |
| smtA | yfhD | HMPREF0621_1630 | HMPREF0621_1135 | Methyltransferase domain protein; COG: COG0500; Pfam: PF08241. | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | 0.485 |
| yfhD | deaD | HMPREF0621_1135 | HMPREF0621_1136 | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | DEAD/DEAH box helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. | 0.527 |
| yfhD | hemY | HMPREF0621_1135 | HMPREF0621_1895 | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | hemY protein; COG: COG3071; Pfam: PF07219; InterPro: IPR005254. | 0.429 |
| yfhD | mutT | HMPREF0621_1135 | HMPREF0621_0801 | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | Hydrolase, NUDIX family; COG: COG0494; Pfam: PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.548 |
| yfhD | plsB | HMPREF0621_1135 | HMPREF0621_0098 | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | Glycerol-3-phosphate O-acyltransferase; COG: COG2937; Pfam: PF01553; InterPro: IPR002123; Belongs to the GPAT/DAPAT family. | 0.409 |
| yfhD | purL | HMPREF0621_1135 | HMPREF0621_1824 | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.514 |
| yfhD | rseB | HMPREF0621_1135 | HMPREF0621_1924 | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | MucB/RseB family protein; COG: COG3026; Pfam: PF03888; InterPro: IPR005588. | 0.566 |
| yfhD | smtA | HMPREF0621_1135 | HMPREF0621_1630 | Transglycosylase SLT domain protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. | Methyltransferase domain protein; COG: COG0500; Pfam: PF08241. | 0.485 |