| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| murP | murQ | HMPREF0621_2012 | HMPREF0621_2011 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | 0.986 |
| murP | ptbA | HMPREF0621_2012 | HMPREF0621_1176 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | PTS system, glucose subfamily, IIA component; COG: COG2190; Pfam: PF00358; InterPro: IPR001127. | 0.999 |
| murP | ptsG | HMPREF0621_2012 | HMPREF0621_0763 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | PTS system, glucose-like IIB component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR003352. | 0.408 |
| murP | ptsH | HMPREF0621_2012 | HMPREF0621_1174 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | Phosphocarrier, HPr family; COG: COG1925; Pfam: PF00381; InterPro: IPR000032. | 0.939 |
| murP | ptsP | HMPREF0621_2012 | HMPREF0621_1175 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). | 0.583 |
| murP | treC | HMPREF0621_2012 | HMPREF0621_0483 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | Alpha,alpha-phosphotrehalase; COG: COG0366; Pfam: PF00128; InterPro: IPR012769. | 0.687 |
| murP | treP | HMPREF0621_2012 | HMPREF0621_0485 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | PTS system trehalose-specific IIBC component; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR011296. | 0.405 |
| murQ | murP | HMPREF0621_2011 | HMPREF0621_2012 | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | 0.986 |
| murQ | nagE | HMPREF0621_2011 | HMPREF0621_0953 | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | PTS system, N-acetylglucosamine-specific IIBC component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR010974. | 0.942 |
| murQ | ptbA | HMPREF0621_2011 | HMPREF0621_1176 | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | PTS system, glucose subfamily, IIA component; COG: COG2190; Pfam: PF00358; InterPro: IPR001127. | 0.911 |
| murQ | ptsG | HMPREF0621_2011 | HMPREF0621_0763 | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | PTS system, glucose-like IIB component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR003352. | 0.446 |
| murQ | scrA | HMPREF0621_2011 | HMPREF0621_1876 | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | PTS system sucrose-specific IIBC component; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR010973. | 0.446 |
| murQ | treP | HMPREF0621_2011 | HMPREF0621_0485 | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | PTS system trehalose-specific IIBC component; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR011296. | 0.446 |
| nagE | murQ | HMPREF0621_0953 | HMPREF0621_2011 | PTS system, N-acetylglucosamine-specific IIBC component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR010974. | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | 0.942 |
| nagE | ptbA | HMPREF0621_0953 | HMPREF0621_1176 | PTS system, N-acetylglucosamine-specific IIBC component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR010974. | PTS system, glucose subfamily, IIA component; COG: COG2190; Pfam: PF00358; InterPro: IPR001127. | 0.997 |
| nagE | ptsH | HMPREF0621_0953 | HMPREF0621_1174 | PTS system, N-acetylglucosamine-specific IIBC component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR010974. | Phosphocarrier, HPr family; COG: COG1925; Pfam: PF00381; InterPro: IPR000032. | 0.939 |
| nagE | ptsP | HMPREF0621_0953 | HMPREF0621_1175 | PTS system, N-acetylglucosamine-specific IIBC component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR010974. | Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). | 0.632 |
| nagE | treC | HMPREF0621_0953 | HMPREF0621_0483 | PTS system, N-acetylglucosamine-specific IIBC component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR010974. | Alpha,alpha-phosphotrehalase; COG: COG0366; Pfam: PF00128; InterPro: IPR012769. | 0.542 |
| pgi | ptbA | HMPREF0621_1484 | HMPREF0621_1176 | Glucose-6-phosphate isomerase; COG: COG0166; Pfam: PF00342; InterPro: IPR001672; Belongs to the GPI family. | PTS system, glucose subfamily, IIA component; COG: COG2190; Pfam: PF00358; InterPro: IPR001127. | 0.934 |
| pgi | ptsG | HMPREF0621_1484 | HMPREF0621_0763 | Glucose-6-phosphate isomerase; COG: COG0166; Pfam: PF00342; InterPro: IPR001672; Belongs to the GPI family. | PTS system, glucose-like IIB component; COG: COG1263; Pfam: PF02378,PF00367; InterPro: IPR003352. | 0.930 |