| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MetI_1 | aad | HMPREF0621_1269 | HMPREF0621_0890 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.593 |
| MetI_1 | betT | HMPREF0621_1269 | HMPREF0621_1920 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | Transporter, betaine/carnitine/choline family; COG: COG1292; Pfam: PF02028; InterPro: IPR000060; Belongs to the BCCT transporter (TC 2.A.15) family. | 0.491 |
| MetI_1 | guaA | HMPREF0621_1269 | HMPREF0621_0382 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.525 |
| MetI_1 | malF | HMPREF0621_1269 | HMPREF0621_0872 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | ABC transporter, permease protein; COG: COG1175; Pfam: PF00528; InterPro: IPR000515. | 0.548 |
| MetI_1 | polA | HMPREF0621_1269 | HMPREF0621_0286 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.538 |
| MetI_1 | proV | HMPREF0621_1269 | HMPREF0621_1268 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | ABC transporter, ATP-binding protein; COG: COG4175; Pfam: PF00005; InterPro: IPR003593. | 0.999 |
| MetI_1 | purM | HMPREF0621_1269 | HMPREF0621_0463 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | Phosphoribosylformylglycinamidine cyclo-ligase; COG: COG0150; Pfam: PF00586,PF02769; InterPro: IPR004733. | 0.674 |
| MetI_1 | purN | HMPREF0621_1269 | HMPREF0621_0464 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.865 |
| MetI_1 | tcyB | HMPREF0621_1269 | HMPREF0621_1787 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | ABC transporter, permease protein; COG: COG0765; Pfam: PF00528; InterPro: IPR000515. | 0.620 |
| MetI_1 | yadH | HMPREF0621_1269 | HMPREF0621_1260 | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | ABC-2 type transporter; COG: COG0842; Pfam: PF01061; InterPro: IPR013525. | 0.475 |
| aad | MetI_1 | HMPREF0621_0890 | HMPREF0621_1269 | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | 0.593 |
| aad | guaA | HMPREF0621_0890 | HMPREF0621_0382 | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.590 |
| aad | polA | HMPREF0621_0890 | HMPREF0621_0286 | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.421 |
| betT | MetI_1 | HMPREF0621_1920 | HMPREF0621_1269 | Transporter, betaine/carnitine/choline family; COG: COG1292; Pfam: PF02028; InterPro: IPR000060; Belongs to the BCCT transporter (TC 2.A.15) family. | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | 0.491 |
| guaA | MetI_1 | HMPREF0621_0382 | HMPREF0621_1269 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | 0.525 |
| guaA | aad | HMPREF0621_0382 | HMPREF0621_0890 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Alcohol dehydrogenase, iron-dependent; COG: COG1454; Pfam: PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.590 |
| guaA | polA | HMPREF0621_0382 | HMPREF0621_0286 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.686 |
| guaA | purM | HMPREF0621_0382 | HMPREF0621_0463 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine cyclo-ligase; COG: COG0150; Pfam: PF00586,PF02769; InterPro: IPR004733. | 0.608 |
| guaA | purN | HMPREF0621_0382 | HMPREF0621_0464 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.581 |
| malF | MetI_1 | HMPREF0621_0872 | HMPREF0621_1269 | ABC transporter, permease protein; COG: COG1175; Pfam: PF00528; InterPro: IPR000515. | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069,PF00528; InterPro: IPR007210. | 0.548 |