| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adk | ampG | HMPREF0621_1503 | HMPREF0621_1502 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.483 |
| adk | galE | HMPREF0621_1503 | HMPREF0621_1501 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | UDP-glucose 4-epimerase; COG: COG1087; Pfam: PF01370; InterPro: IPR005886; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | 0.489 |
| ampD | ampG | HMPREF0621_1097 | HMPREF0621_1502 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.440 |
| ampD | nagZ | HMPREF0621_1097 | HMPREF0621_1109 | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.497 |
| ampG | adk | HMPREF0621_1502 | HMPREF0621_1503 | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.483 |
| ampG | ampD | HMPREF0621_1502 | HMPREF0621_1097 | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | 0.440 |
| ampG | galE | HMPREF0621_1502 | HMPREF0621_1501 | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | UDP-glucose 4-epimerase; COG: COG1087; Pfam: PF01370; InterPro: IPR005886; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | 0.779 |
| ampG | menF | HMPREF0621_1502 | HMPREF0621_1126 | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.670 |
| ampG | nagZ | HMPREF0621_1502 | HMPREF0621_1109 | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.485 |
| ampG | yfiO | HMPREF0621_1502 | HMPREF0621_0007 | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Outer membrane assembly lipoprotein YfiO; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.498 |
| galE | adk | HMPREF0621_1501 | HMPREF0621_1503 | UDP-glucose 4-epimerase; COG: COG1087; Pfam: PF01370; InterPro: IPR005886; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.489 |
| galE | ampG | HMPREF0621_1501 | HMPREF0621_1502 | UDP-glucose 4-epimerase; COG: COG1087; Pfam: PF01370; InterPro: IPR005886; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.779 |
| menF | ampG | HMPREF0621_1126 | HMPREF0621_1502 | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.670 |
| nagZ | ampD | HMPREF0621_1109 | HMPREF0621_1097 | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | N-acetylmuramoyl-L-alanine amidase; COG: COG3023; Pfam: PF01510; InterPro: IPR002502. | 0.497 |
| nagZ | ampG | HMPREF0621_1109 | HMPREF0621_1502 | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.485 |
| yfiO | ampG | HMPREF0621_0007 | HMPREF0621_1502 | Outer membrane assembly lipoprotein YfiO; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | AmpG-related permease; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.498 |