| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX50055.1 | pntA | HMPREF0621_1578 | HMPREF0621_1580 | Hypothetical protein; COG: COG3663. | NAD(P)(+) transhydrogenase (AB-specific), alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.502 |
| EEX50055.1 | pntB | HMPREF0621_1578 | HMPREF0621_1579 | Hypothetical protein; COG: COG3663. | NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.506 |
| NadR | cobB | HMPREF0621_1980 | HMPREF0621_0039 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | 0.992 |
| NadR | mazG | HMPREF0621_1980 | HMPREF0621_0722 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | MazG family protein; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | 0.907 |
| NadR | nudC | HMPREF0621_1980 | HMPREF0621_0620 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Hydrolase, NUDIX family; COG: COG2816; Pfam: PF09296,PF09297,PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.901 |
| NadR | pntA | HMPREF0621_1980 | HMPREF0621_1580 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | NAD(P)(+) transhydrogenase (AB-specific), alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.900 |
| NadR | pntB | HMPREF0621_1980 | HMPREF0621_1579 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |
| NadR | ppnK | HMPREF0621_1980 | HMPREF0621_0310 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.944 |
| aspC | pntA | HMPREF0621_1368 | HMPREF0621_1580 | Aminotransferase, class I/II; COG: COG1448; Pfam: PF00155; InterPro: IPR000796. | NAD(P)(+) transhydrogenase (AB-specific), alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.409 |
| aspC | pntB | HMPREF0621_1368 | HMPREF0621_1579 | Aminotransferase, class I/II; COG: COG1448; Pfam: PF00155; InterPro: IPR000796. | NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.404 |
| cobB | NadR | HMPREF0621_0039 | HMPREF0621_1980 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.992 |
| cobB | mazG | HMPREF0621_0039 | HMPREF0621_0722 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | MazG family protein; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | 0.900 |
| cobB | nudC | HMPREF0621_0039 | HMPREF0621_0620 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | Hydrolase, NUDIX family; COG: COG2816; Pfam: PF09296,PF09297,PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.905 |
| cobB | pntA | HMPREF0621_0039 | HMPREF0621_1580 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | NAD(P)(+) transhydrogenase (AB-specific), alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.903 |
| cobB | pntB | HMPREF0621_0039 | HMPREF0621_1579 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | NAD(P) transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |
| cobB | ppnK | HMPREF0621_0039 | HMPREF0621_0310 | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.920 |
| mazG | NadR | HMPREF0621_0722 | HMPREF0621_1980 | MazG family protein; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.907 |
| mazG | cobB | HMPREF0621_0722 | HMPREF0621_0039 | MazG family protein; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | 0.900 |
| mazG | nudC | HMPREF0621_0722 | HMPREF0621_0620 | MazG family protein; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | Hydrolase, NUDIX family; COG: COG2816; Pfam: PF09296,PF09297,PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. NudC subfamily. | 0.906 |
| mazG | pntA | HMPREF0621_0722 | HMPREF0621_1580 | MazG family protein; COG: COG1694; Pfam: PF03819; InterPro: IPR011551. | NAD(P)(+) transhydrogenase (AB-specific), alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.900 |