STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (321 aa)    
Predicted Functional Partners:
hemG
Putative protoporphyrinogen oxidase; COG: COG4635.
    
 0.924
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.876
EEX49631.1
FAD linked oxidase, C-terminal domain protein; COG: COG0277; Pfam: PF01565,PF02913,PF00037; InterPro: IPR004113.
       0.803
EEX49632.1
Hypothetical protein; COG: COG2050; Pfam: PF03061; InterPro: IPR003736; 3.1.-.-.
       0.794
cyaY
Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
    
 
 0.588
hemN
Coproporphyrinogen dehydrogenase; COG: COG0635; Pfam: PF04055,PF06969; InterPro: IPR004558; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
  
 0.509
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
  
 0.482
hemB
Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family.
 
  
 0.477
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; COG: COG0001; Pfam: PF00202; InterPro: IPR004639.
 
  
 0.459
metG
methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
  
 0.411
Your Current Organism:
Pasteurella dagmatis
NCBI taxonomy Id: 667128
Other names: P. dagmatis ATCC 43325, Pasteurella dagmatis ATCC 43325, Pasteurella dagmatis str. ATCC 43325, Pasteurella dagmatis strain ATCC 43325
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