| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX49544.1 | cyaA | HMPREF0621_1899 | HMPREF0621_1900 | Hypothetical protein. | Adenylate cyclase, class I; COG: COG3072; Pfam: PF01295; InterPro: IPR000274; Belongs to the adenylyl cyclase class-1 family. | 0.567 |
| EEX49544.1 | hemC | HMPREF0621_1899 | HMPREF0621_1898 | Hypothetical protein. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.773 |
| EEX49544.1 | hemD | HMPREF0621_1899 | HMPREF0621_1897 | Hypothetical protein. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.752 |
| EEX49544.1 | narL | HMPREF0621_1899 | HMPREF0621_1901 | Hypothetical protein. | Response regulator receiver domain protein; COG: COG2197; Pfam: PF00072,PF00196; InterPro: IPR001789. | 0.536 |
| arcB | cvgSY | HMPREF0621_1142 | HMPREF0621_1966 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518,PF00072,PF01627; InterPro: IPR003594. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00672,PF00512,PF02518,PF00072; InterPro: IPR003594. | 0.879 |
| arcB | narL | HMPREF0621_1142 | HMPREF0621_1901 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518,PF00072,PF01627; InterPro: IPR003594. | Response regulator receiver domain protein; COG: COG2197; Pfam: PF00072,PF00196; InterPro: IPR001789. | 0.999 |
| arcB | narQ | HMPREF0621_1142 | HMPREF0621_0815 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518,PF00072,PF01627; InterPro: IPR003594. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG3850; Pfam: PF00672,PF07730,PF02518; InterPro: IPR003594. | 0.469 |
| arcB | ompR | HMPREF0621_1142 | HMPREF0621_1961 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518,PF00072,PF01627; InterPro: IPR003594. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.999 |
| arcB | qseC | HMPREF0621_1142 | HMPREF0621_1727 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518,PF00072,PF01627; InterPro: IPR003594. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00672,PF00512,PF02518; InterPro: IPR003594. | 0.999 |
| arcB | ttrS | HMPREF0621_1142 | HMPREF0621_1243 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518,PF00072,PF01627; InterPro: IPR003594. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Pfam: PF00512,PF02518; InterPro: IPR003594. | 0.912 |
| cvgSY | arcB | HMPREF0621_1966 | HMPREF0621_1142 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00672,PF00512,PF02518,PF00072; InterPro: IPR003594. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00512,PF02518,PF00072,PF01627; InterPro: IPR003594. | 0.879 |
| cvgSY | narL | HMPREF0621_1966 | HMPREF0621_1901 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00672,PF00512,PF02518,PF00072; InterPro: IPR003594. | Response regulator receiver domain protein; COG: COG2197; Pfam: PF00072,PF00196; InterPro: IPR001789. | 0.559 |
| cvgSY | ompR | HMPREF0621_1966 | HMPREF0621_1961 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00672,PF00512,PF02518,PF00072; InterPro: IPR003594. | Response regulator receiver domain protein; COG: COG0745; Pfam: PF00072,PF00486; InterPro: IPR001789. | 0.575 |
| cvgSY | qseC | HMPREF0621_1966 | HMPREF0621_1727 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00672,PF00512,PF02518,PF00072; InterPro: IPR003594. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00672,PF00512,PF02518; InterPro: IPR003594. | 0.525 |
| cvgSY | ttrS | HMPREF0621_1966 | HMPREF0621_1243 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG0642; Pfam: PF00672,PF00512,PF02518,PF00072; InterPro: IPR003594. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; Pfam: PF00512,PF02518; InterPro: IPR003594. | 0.619 |
| cyaA | EEX49544.1 | HMPREF0621_1900 | HMPREF0621_1899 | Adenylate cyclase, class I; COG: COG3072; Pfam: PF01295; InterPro: IPR000274; Belongs to the adenylyl cyclase class-1 family. | Hypothetical protein. | 0.567 |
| cyaA | hemC | HMPREF0621_1900 | HMPREF0621_1898 | Adenylate cyclase, class I; COG: COG3072; Pfam: PF01295; InterPro: IPR000274; Belongs to the adenylyl cyclase class-1 family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.607 |
| cyaA | hemD | HMPREF0621_1900 | HMPREF0621_1897 | Adenylate cyclase, class I; COG: COG3072; Pfam: PF01295; InterPro: IPR000274; Belongs to the adenylyl cyclase class-1 family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.656 |
| cyaA | narL | HMPREF0621_1900 | HMPREF0621_1901 | Adenylate cyclase, class I; COG: COG3072; Pfam: PF01295; InterPro: IPR000274; Belongs to the adenylyl cyclase class-1 family. | Response regulator receiver domain protein; COG: COG2197; Pfam: PF00072,PF00196; InterPro: IPR001789. | 0.749 |
| hemC | EEX49544.1 | HMPREF0621_1898 | HMPREF0621_1899 | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Hypothetical protein. | 0.773 |