| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX49438.1 | NadR | HMPREF0621_1981 | HMPREF0621_1980 | Ser/Thr phosphatase family protein; Pfam: PF00149. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.880 |
| EEX49438.1 | YqiC | HMPREF0621_1981 | HMPREF0621_1979 | Ser/Thr phosphatase family protein; Pfam: PF00149. | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | 0.584 |
| EEX49731.1 | YqiC | HMPREF0621_1778 | HMPREF0621_1979 | Hypothetical protein; COG: COG2914; Pfam: PF03658; InterPro: IPR005346; Belongs to the UPF0125 (RnfH) family. | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | 0.593 |
| EEX50946.1 | YigP | HMPREF0621_0533 | HMPREF0621_0602 | Hypothetical protein; COG: COG3082; Pfam: PF07208; InterPro: IPR009857; Belongs to the UPF0352 family. | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | 0.690 |
| EEX50946.1 | YqiC | HMPREF0621_0533 | HMPREF0621_1979 | Hypothetical protein; COG: COG3082; Pfam: PF07208; InterPro: IPR009857; Belongs to the UPF0352 family. | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | 0.522 |
| EEX50946.1 | seqA | HMPREF0621_0533 | HMPREF0621_0983 | Hypothetical protein; COG: COG3082; Pfam: PF07208; InterPro: IPR009857; Belongs to the UPF0352 family. | SeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.774 |
| EEX50946.1 | smtA | HMPREF0621_0533 | HMPREF0621_1630 | Hypothetical protein; COG: COG3082; Pfam: PF07208; InterPro: IPR009857; Belongs to the UPF0352 family. | Methyltransferase domain protein; COG: COG0500; Pfam: PF08241. | 0.535 |
| NadR | EEX49438.1 | HMPREF0621_1980 | HMPREF0621_1981 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Ser/Thr phosphatase family protein; Pfam: PF00149. | 0.880 |
| NadR | YqiC | HMPREF0621_1980 | HMPREF0621_1979 | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | 0.634 |
| YigP | EEX50946.1 | HMPREF0621_0602 | HMPREF0621_0533 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Hypothetical protein; COG: COG3082; Pfam: PF07208; InterPro: IPR009857; Belongs to the UPF0352 family. | 0.690 |
| YigP | YqiC | HMPREF0621_0602 | HMPREF0621_1979 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | 0.593 |
| YigP | seqA | HMPREF0621_0602 | HMPREF0621_0983 | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | SeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.493 |
| YqiC | EEX49438.1 | HMPREF0621_1979 | HMPREF0621_1981 | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | Ser/Thr phosphatase family protein; Pfam: PF00149. | 0.584 |
| YqiC | EEX49731.1 | HMPREF0621_1979 | HMPREF0621_1778 | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | Hypothetical protein; COG: COG2914; Pfam: PF03658; InterPro: IPR005346; Belongs to the UPF0125 (RnfH) family. | 0.593 |
| YqiC | EEX50946.1 | HMPREF0621_1979 | HMPREF0621_0533 | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | Hypothetical protein; COG: COG3082; Pfam: PF07208; InterPro: IPR009857; Belongs to the UPF0352 family. | 0.522 |
| YqiC | NadR | HMPREF0621_1979 | HMPREF0621_1980 | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | Nicotinamide-nucleotide adenylyltransferase; COG: COG3172; Pfam: PF01381; InterPro: IPR006417. | 0.634 |
| YqiC | YigP | HMPREF0621_1979 | HMPREF0621_0602 | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | SCP-2 sterol transfer family protein; COG: COG3165; Pfam: PF06843; InterPro: IPR010668. | 0.593 |
| YqiC | cca | HMPREF0621_1979 | HMPREF0621_1223 | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | tRNA nucleotidyltransferase/poly(A) polymerase family protein; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. | 0.489 |
| YqiC | gltX | HMPREF0621_1979 | HMPREF0621_1140 | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.495 |
| YqiC | mreD | HMPREF0621_1979 | HMPREF0621_0230 | Hypothetical protein; COG: COG2960; Pfam: PF04380; InterPro: IPR007475. | Rod shape-determining protein MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family. | 0.477 |