| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX49394.1 | EEX50379.1 | HMPREF0621_2030 | HMPREF0621_1002 | Tetratricopeptide repeat protein; Pfam: PF04575; InterPro: IPR007655. | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | 0.723 |
| EEX49394.1 | eriC | HMPREF0621_2030 | HMPREF0621_2009 | Tetratricopeptide repeat protein; Pfam: PF04575; InterPro: IPR007655. | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | 0.462 |
| EEX50379.1 | EEX49394.1 | HMPREF0621_1002 | HMPREF0621_2030 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Tetratricopeptide repeat protein; Pfam: PF04575; InterPro: IPR007655. | 0.723 |
| EEX50379.1 | eriC | HMPREF0621_1002 | HMPREF0621_2009 | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | 0.406 |
| dusA | eriC | HMPREF0621_2010 | HMPREF0621_2009 | tRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | 0.794 |
| dusA | murP | HMPREF0621_2010 | HMPREF0621_2012 | tRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | 0.432 |
| dusA | murQ | HMPREF0621_2010 | HMPREF0621_2011 | tRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | 0.465 |
| dusA | rpsJ | HMPREF0621_2010 | HMPREF0621_2008 | tRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. | 0.451 |
| eriC | EEX49394.1 | HMPREF0621_2009 | HMPREF0621_2030 | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | Tetratricopeptide repeat protein; Pfam: PF04575; InterPro: IPR007655. | 0.462 |
| eriC | EEX50379.1 | HMPREF0621_2009 | HMPREF0621_1002 | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | Hypothetical protein; COG: COG2990; Pfam: PF04393; InterPro: IPR007488. | 0.406 |
| eriC | dusA | HMPREF0621_2009 | HMPREF0621_2010 | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | tRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | 0.794 |
| eriC | kefC | HMPREF0621_2009 | HMPREF0621_0480 | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.411 |
| eriC | murP | HMPREF0621_2009 | HMPREF0621_2012 | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | 0.432 |
| eriC | murQ | HMPREF0621_2009 | HMPREF0621_2011 | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | 0.465 |
| eriC | putA | HMPREF0621_2009 | HMPREF0621_1408 | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.503 |
| eriC | rpsJ | HMPREF0621_2009 | HMPREF0621_2008 | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. | 0.404 |
| kefC | eriC | HMPREF0621_0480 | HMPREF0621_2009 | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | 0.411 |
| murP | dusA | HMPREF0621_2012 | HMPREF0621_2010 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | tRNA dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | 0.432 |
| murP | eriC | HMPREF0621_2012 | HMPREF0621_2009 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | Chloride transporter, ClC family; COG: COG0038; Pfam: PF00654; InterPro: IPR001807. | 0.432 |
| murP | murQ | HMPREF0621_2012 | HMPREF0621_2011 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | 0.986 |