| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FruB | Mlc | HMPREF0621_1914 | HMPREF0621_1388 | Hypothetical protein; 2.7.1.-. | Hypothetical protein. | 0.442 |
| FruB | manX | HMPREF0621_1914 | HMPREF0621_1718 | Hypothetical protein; 2.7.1.-. | PTS system, mannose/fructose/sorbose family, IIB component; COG: COG3444; Pfam: PF03610,PF03830; InterPro: IPR004720. | 0.966 |
| FruB | murP | HMPREF0621_1914 | HMPREF0621_2012 | Hypothetical protein; 2.7.1.-. | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | 0.716 |
| FruB | ptbA | HMPREF0621_1914 | HMPREF0621_1176 | Hypothetical protein; 2.7.1.-. | PTS system, glucose subfamily, IIA component; COG: COG2190; Pfam: PF00358; InterPro: IPR001127. | 0.713 |
| FruB | scrB | HMPREF0621_1914 | HMPREF0621_1874 | Hypothetical protein; 2.7.1.-. | Sucrose-6-phosphate hydrolase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. | 0.468 |
| Mlc | FruB | HMPREF0621_1388 | HMPREF0621_1914 | Hypothetical protein. | Hypothetical protein; 2.7.1.-. | 0.442 |
| Mlc | murP | HMPREF0621_1388 | HMPREF0621_2012 | Hypothetical protein. | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | 0.697 |
| anmK | murP | HMPREF0621_1890 | HMPREF0621_2012 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | 0.918 |
| anmK | murQ | HMPREF0621_1890 | HMPREF0621_2011 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | 0.996 |
| anmK | ptbA | HMPREF0621_1890 | HMPREF0621_1176 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | PTS system, glucose subfamily, IIA component; COG: COG2190; Pfam: PF00358; InterPro: IPR001127. | 0.900 |
| manX | FruB | HMPREF0621_1718 | HMPREF0621_1914 | PTS system, mannose/fructose/sorbose family, IIB component; COG: COG3444; Pfam: PF03610,PF03830; InterPro: IPR004720. | Hypothetical protein; 2.7.1.-. | 0.966 |
| manX | murP | HMPREF0621_1718 | HMPREF0621_2012 | PTS system, mannose/fructose/sorbose family, IIB component; COG: COG3444; Pfam: PF03610,PF03830; InterPro: IPR004720. | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | 0.721 |
| manX | ptbA | HMPREF0621_1718 | HMPREF0621_1176 | PTS system, mannose/fructose/sorbose family, IIB component; COG: COG3444; Pfam: PF03610,PF03830; InterPro: IPR004720. | PTS system, glucose subfamily, IIA component; COG: COG2190; Pfam: PF00358; InterPro: IPR001127. | 0.552 |
| manX | ptsH | HMPREF0621_1718 | HMPREF0621_1174 | PTS system, mannose/fructose/sorbose family, IIB component; COG: COG3444; Pfam: PF03610,PF03830; InterPro: IPR004720. | Phosphocarrier, HPr family; COG: COG1925; Pfam: PF00381; InterPro: IPR000032. | 0.989 |
| manX | scrB | HMPREF0621_1718 | HMPREF0621_1874 | PTS system, mannose/fructose/sorbose family, IIB component; COG: COG3444; Pfam: PF03610,PF03830; InterPro: IPR004720. | Sucrose-6-phosphate hydrolase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. | 0.531 |
| murP | FruB | HMPREF0621_2012 | HMPREF0621_1914 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | Hypothetical protein; 2.7.1.-. | 0.716 |
| murP | Mlc | HMPREF0621_2012 | HMPREF0621_1388 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | Hypothetical protein. | 0.697 |
| murP | anmK | HMPREF0621_2012 | HMPREF0621_1890 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.918 |
| murP | manX | HMPREF0621_2012 | HMPREF0621_1718 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | PTS system, mannose/fructose/sorbose family, IIB component; COG: COG3444; Pfam: PF03610,PF03830; InterPro: IPR004720. | 0.721 |
| murP | murQ | HMPREF0621_2012 | HMPREF0621_2011 | N-acetylmuramic acid phosphotransfer permease; COG: COG1263; Pfam: PF00367,PF02378; InterPro: IPR003352. | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | 0.984 |