| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KfoC | def | HMPREF0621_2018 | HMPREF0621_2021 | Glycosyltransferase, group 2 family protein; COG: COG0463; Pfam: PF00535; InterPro: IPR001173. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.594 |
| KfoC | fmt | HMPREF0621_2018 | HMPREF0621_2020 | Glycosyltransferase, group 2 family protein; COG: COG0463; Pfam: PF00535; InterPro: IPR001173. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.778 |
| KfoC | mscL | HMPREF0621_2018 | HMPREF0621_2016 | Glycosyltransferase, group 2 family protein; COG: COG0463; Pfam: PF00535; InterPro: IPR001173. | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.533 |
| KfoC | sun | HMPREF0621_2018 | HMPREF0621_2019 | Glycosyltransferase, group 2 family protein; COG: COG0463; Pfam: PF00535; InterPro: IPR001173. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.765 |
| KfoC | trkA | HMPREF0621_2018 | HMPREF0621_2017 | Glycosyltransferase, group 2 family protein; COG: COG0463; Pfam: PF00535; InterPro: IPR001173. | Potassium transporter peripheral membrane component; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.785 |
| def | KfoC | HMPREF0621_2021 | HMPREF0621_2018 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Glycosyltransferase, group 2 family protein; COG: COG0463; Pfam: PF00535; InterPro: IPR001173. | 0.594 |
| def | fmt | HMPREF0621_2021 | HMPREF0621_2020 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.961 |
| def | mscL | HMPREF0621_2021 | HMPREF0621_2016 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.429 |
| def | sun | HMPREF0621_2021 | HMPREF0621_2019 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.813 |
| def | trkA | HMPREF0621_2021 | HMPREF0621_2017 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | Potassium transporter peripheral membrane component; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.635 |
| fmt | KfoC | HMPREF0621_2020 | HMPREF0621_2018 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycosyltransferase, group 2 family protein; COG: COG0463; Pfam: PF00535; InterPro: IPR001173. | 0.778 |
| fmt | def | HMPREF0621_2020 | HMPREF0621_2021 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.961 |
| fmt | mscL | HMPREF0621_2020 | HMPREF0621_2016 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.552 |
| fmt | sun | HMPREF0621_2020 | HMPREF0621_2019 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.992 |
| fmt | trkA | HMPREF0621_2020 | HMPREF0621_2017 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Potassium transporter peripheral membrane component; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.806 |
| hemD | trkA | HMPREF0621_1897 | HMPREF0621_2017 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Potassium transporter peripheral membrane component; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.472 |
| kefC | trkA | HMPREF0621_0480 | HMPREF0621_2017 | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | Potassium transporter peripheral membrane component; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.429 |
| kefC | trkH | HMPREF0621_0480 | HMPREF0621_0931 | Transporter, CPA2 family; COG: COG0475; Pfam: PF00999,PF02254; InterPro: IPR006153; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | Potassium uptake protein, TrkH family; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family. | 0.460 |
| moaE | trkA | HMPREF0621_1369 | HMPREF0621_2017 | Molybdopterin converting factor, subunit 2; COG: COG0314; Pfam: PF02391; InterPro: IPR003448. | Potassium transporter peripheral membrane component; COG: COG0569; Pfam: PF02254,PF02080; InterPro: IPR016040. | 0.578 |
| mscL | KfoC | HMPREF0621_2016 | HMPREF0621_2018 | Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | Glycosyltransferase, group 2 family protein; COG: COG0463; Pfam: PF00535; InterPro: IPR001173. | 0.533 |