| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| eno | fba | HMPREF0621_0036 | HMPREF0621_1958 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | 0.937 |
| eno | fbaA | HMPREF0621_0036 | HMPREF0621_1859 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | 0.937 |
| eno | gpm | HMPREF0621_0036 | HMPREF0621_2038 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.974 |
| eno | pgi | HMPREF0621_0036 | HMPREF0621_1484 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Glucose-6-phosphate isomerase; COG: COG0166; Pfam: PF00342; InterPro: IPR001672; Belongs to the GPI family. | 0.970 |
| eno | pgk | HMPREF0621_0036 | HMPREF0621_1861 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Phosphoglycerate kinase; COG: COG0126; Pfam: PF00162; InterPro: IPR001576; Belongs to the phosphoglycerate kinase family. | 0.978 |
| eno | tal | HMPREF0621_0036 | HMPREF0621_0803 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.895 |
| eno | tkt | HMPREF0621_0036 | HMPREF0621_0756 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.926 |
| eno | zwf | HMPREF0621_0036 | HMPREF0621_0844 | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.855 |
| fba | eno | HMPREF0621_1958 | HMPREF0621_0036 | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | 0.937 |
| fba | fbaA | HMPREF0621_1958 | HMPREF0621_1859 | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | 0.917 |
| fba | gpm | HMPREF0621_1958 | HMPREF0621_2038 | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.885 |
| fba | pgi | HMPREF0621_1958 | HMPREF0621_1484 | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | Glucose-6-phosphate isomerase; COG: COG0166; Pfam: PF00342; InterPro: IPR001672; Belongs to the GPI family. | 0.927 |
| fba | pgk | HMPREF0621_1958 | HMPREF0621_1861 | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | Phosphoglycerate kinase; COG: COG0126; Pfam: PF00162; InterPro: IPR001576; Belongs to the phosphoglycerate kinase family. | 0.778 |
| fba | tal | HMPREF0621_1958 | HMPREF0621_0803 | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.933 |
| fba | tkt | HMPREF0621_1958 | HMPREF0621_0756 | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.934 |
| fba | zwf | HMPREF0621_1958 | HMPREF0621_0844 | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.823 |
| fbaA | eno | HMPREF0621_1859 | HMPREF0621_0036 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | 0.937 |
| fbaA | fba | HMPREF0621_1859 | HMPREF0621_1958 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Ketose-bisphosphate aldolase; COG: COG0191; Pfam: PF01116; InterPro: IPR013785. | 0.917 |
| fbaA | gpm | HMPREF0621_1859 | HMPREF0621_2038 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.885 |
| fbaA | pgi | HMPREF0621_1859 | HMPREF0621_1484 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Glucose-6-phosphate isomerase; COG: COG0166; Pfam: PF00342; InterPro: IPR001672; Belongs to the GPI family. | 0.927 |