| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adk | apt | HMPREF0758_0154 | HMPREF0758_0160 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.951 |
| adk | gmk | HMPREF0758_0154 | HMPREF0758_1278 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.790 |
| adk | guaA-2 | HMPREF0758_0154 | HMPREF0758_2515 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.513 |
| adk | hpt | HMPREF0758_0154 | HMPREF0758_2151 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Pfam: PF00156; InterPro: IPR005904; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.927 |
| adk | purB | HMPREF0758_0154 | HMPREF0758_4142 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate lyase; COG: COG0015; Pfam: PF00206,PF08328; InterPro: IPR004769; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.955 |
| apt | adk | HMPREF0758_0160 | HMPREF0758_0154 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.951 |
| apt | gmk | HMPREF0758_0160 | HMPREF0758_1278 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.957 |
| apt | gpt | HMPREF0758_0160 | HMPREF0758_0320 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.935 |
| apt | gsk | HMPREF0758_0160 | HMPREF0758_0149 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294; InterPro: IPR011611. | 0.931 |
| apt | guaA | HMPREF0758_0160 | HMPREF0758_1907 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Class I glutamine amidotransferase; COG: COG0518; Pfam: PF00117; InterPro: IPR000991. | 0.924 |
| apt | guaA-2 | HMPREF0758_0160 | HMPREF0758_2515 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.988 |
| apt | guaC | HMPREF0758_0160 | HMPREF0758_0499 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.926 |
| apt | hpt | HMPREF0758_0160 | HMPREF0758_2151 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Pfam: PF00156; InterPro: IPR005904; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.926 |
| apt | purB | HMPREF0758_0160 | HMPREF0758_4142 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; COG: COG0015; Pfam: PF00206,PF08328; InterPro: IPR004769; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.948 |
| apt | purH | HMPREF0758_0160 | HMPREF0758_1679 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.957 |
| gmk | adk | HMPREF0758_1278 | HMPREF0758_0154 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.790 |
| gmk | apt | HMPREF0758_1278 | HMPREF0758_0160 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.957 |
| gmk | gpt | HMPREF0758_1278 | HMPREF0758_0320 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.957 |
| gmk | gsk | HMPREF0758_1278 | HMPREF0758_0149 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Kinase, PfkB family; COG: COG0524; Pfam: PF00294; InterPro: IPR011611. | 0.906 |
| gmk | guaA | HMPREF0758_1278 | HMPREF0758_1907 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Class I glutamine amidotransferase; COG: COG0518; Pfam: PF00117; InterPro: IPR000991. | 0.917 |