| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| acnA | amt | HMPREF0758_3563 | HMPREF0758_0185 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | 0.521 |
| acnA | gltB | HMPREF0758_3563 | HMPREF0758_1877 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.615 |
| acnA | uca | HMPREF0758_3563 | HMPREF0758_4718 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Urea carboxylase; COG: COG0439; Pfam: PF00289,PF02786,PF02785,PF02626,PF02682,PF00364; InterPro: IPR014084. | 0.527 |
| amt | acnA | HMPREF0758_0185 | HMPREF0758_3563 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.521 |
| amt | aspA | HMPREF0758_0185 | HMPREF0758_0894 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | Aspartate ammonia-lyase; COG: COG1027; Pfam: PF00206; InterPro: IPR004708. | 0.491 |
| amt | glnB | HMPREF0758_0185 | HMPREF0758_0186 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family. | 0.999 |
| amt | glnB2 | HMPREF0758_0185 | HMPREF0758_2476 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family. | 0.997 |
| amt | glnD | HMPREF0758_0185 | HMPREF0758_2327 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.543 |
| amt | glnL | HMPREF0758_0185 | HMPREF0758_1298 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG3852; Pfam: PF00989,PF00512,PF02518; InterPro: IPR003594. | 0.810 |
| amt | gltB | HMPREF0758_0185 | HMPREF0758_1877 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.808 |
| amt | nadE | HMPREF0758_0185 | HMPREF0758_2475 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.572 |
| amt | rubA | HMPREF0758_0185 | HMPREF0758_0910 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | Rubredoxin; COG: COG1773; Pfam: PF00301; InterPro: IPR004039; Belongs to the rubredoxin family. | 0.495 |
| amt | uca | HMPREF0758_0185 | HMPREF0758_4718 | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | Urea carboxylase; COG: COG0439; Pfam: PF00289,PF02786,PF02785,PF02626,PF02682,PF00364; InterPro: IPR014084. | 0.491 |
| aspA | amt | HMPREF0758_0894 | HMPREF0758_0185 | Aspartate ammonia-lyase; COG: COG1027; Pfam: PF00206; InterPro: IPR004708. | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | 0.491 |
| glnB | amt | HMPREF0758_0186 | HMPREF0758_0185 | Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family. | Ammonium transporter; COG: COG0004; Pfam: PF00909; InterPro: IPR001905. | 0.999 |
| glnB | glnB2 | HMPREF0758_0186 | HMPREF0758_2476 | Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family. | Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family. | 0.677 |
| glnB | glnD | HMPREF0758_0186 | HMPREF0758_2327 | Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.851 |
| glnB | glnL | HMPREF0758_0186 | HMPREF0758_1298 | Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; COG: COG3852; Pfam: PF00989,PF00512,PF02518; InterPro: IPR003594. | 0.795 |
| glnB | gltB | HMPREF0758_0186 | HMPREF0758_1877 | Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.625 |
| glnB | nadE | HMPREF0758_0186 | HMPREF0758_2475 | Nitrogen regulatory protein P-II; COG: COG0347; Pfam: PF00543; InterPro: IPR015867; Belongs to the P(II) protein family. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.500 |