| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE98159.1 | ampG | HMPREF0758_0204 | HMPREF0758_0205 | Hypothetical protein; COG: COG3056; Pfam: PF03923; InterPro: IPR005619. | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.641 |
| EFE98159.1 | bolA | HMPREF0758_0204 | HMPREF0758_0203 | Hypothetical protein; COG: COG3056; Pfam: PF03923; InterPro: IPR005619. | Protein BolA; COG: COG0271; Pfam: PF01722; InterPro: IPR002634; Belongs to the BolA/IbaG family. | 0.445 |
| ampG | EFE98159.1 | HMPREF0758_0205 | HMPREF0758_0204 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Hypothetical protein; COG: COG3056; Pfam: PF03923; InterPro: IPR005619. | 0.641 |
| ampG | anmK | HMPREF0758_0205 | HMPREF0758_3902 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.480 |
| ampG | bolA | HMPREF0758_0205 | HMPREF0758_0203 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Protein BolA; COG: COG0271; Pfam: PF01722; InterPro: IPR002634; Belongs to the BolA/IbaG family. | 0.404 |
| ampG | dacB | HMPREF0758_0205 | HMPREF0758_0814 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; COG: COG2027; Pfam: PF02113; InterPro: IPR000667. | 0.443 |
| ampG | entC | HMPREF0758_0205 | HMPREF0758_2682 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | 0.646 |
| ampG | entE | HMPREF0758_0205 | HMPREF0758_2683 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | (2,3-dihydroxybenzoyl)adenylate synthase; COG: COG1021; Pfam: PF00501; InterPro: IPR011963. | 0.669 |
| ampG | menF | HMPREF0758_0205 | HMPREF0758_2815 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.646 |
| ampG | mltA | HMPREF0758_0205 | HMPREF0758_2309 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | MltA specific insert domain protein; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. | 0.424 |
| ampG | nagZ | HMPREF0758_0205 | HMPREF0758_4172 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.559 |
| ampG | rlpA | HMPREF0758_0205 | HMPREF0758_4918 | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | Sporulation and cell division repeat protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.404 |
| anmK | ampG | HMPREF0758_3902 | HMPREF0758_0205 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.480 |
| anmK | nagZ | HMPREF0758_3902 | HMPREF0758_4172 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | Glycosyl hydrolase family 3 N-terminal domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.639 |
| bolA | EFE98159.1 | HMPREF0758_0203 | HMPREF0758_0204 | Protein BolA; COG: COG0271; Pfam: PF01722; InterPro: IPR002634; Belongs to the BolA/IbaG family. | Hypothetical protein; COG: COG3056; Pfam: PF03923; InterPro: IPR005619. | 0.445 |
| bolA | ampG | HMPREF0758_0203 | HMPREF0758_0205 | Protein BolA; COG: COG0271; Pfam: PF01722; InterPro: IPR002634; Belongs to the BolA/IbaG family. | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.404 |
| dacB | ampG | HMPREF0758_0814 | HMPREF0758_0205 | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; COG: COG2027; Pfam: PF02113; InterPro: IPR000667. | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.443 |
| dacB | mltA | HMPREF0758_0814 | HMPREF0758_2309 | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; COG: COG2027; Pfam: PF02113; InterPro: IPR000667. | MltA specific insert domain protein; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. | 0.467 |
| entC | ampG | HMPREF0758_2682 | HMPREF0758_0205 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | Muropeptide transporter; COG: COG0477; Pfam: PF07690; InterPro: IPR011701. | 0.646 |
| entC | entE | HMPREF0758_2682 | HMPREF0758_2683 | Isochorismate synthase; COG: COG1169; Pfam: PF00425; InterPro: IPR004561. | (2,3-dihydroxybenzoyl)adenylate synthase; COG: COG1021; Pfam: PF00501; InterPro: IPR011963. | 0.987 |