| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| XecA1 | luxS | HMPREF0758_0297 | HMPREF0758_0419 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.914 |
| XecA1 | metB | HMPREF0758_0297 | HMPREF0758_1161 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Cystathionine gamma-synthase; COG: COG0626; Pfam: PF01053; InterPro: IPR011821. | 0.933 |
| XecA1 | metC | HMPREF0758_0297 | HMPREF0758_0469 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Putative methionine gamma-lyase; COG: COG0626; Pfam: PF01053; InterPro: IPR000277. | 0.933 |
| XecA1 | metC-2 | HMPREF0758_0297 | HMPREF0758_1976 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Cystathionine beta-lyase; COG: COG0626; Pfam: PF01053; InterPro: IPR006233. | 0.933 |
| XecA1 | metC-3 | HMPREF0758_0297 | HMPREF0758_2010 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Cystathionine beta-lyase; COG: COG0626; Pfam: PF01053; InterPro: IPR006233. | 0.933 |
| XecA1 | metC5 | HMPREF0758_0297 | HMPREF0758_4526 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Cys/Met metabolism PLP-dependent enzyme; COG: COG0626; Pfam: PF01053; InterPro: IPR000277. | 0.933 |
| XecA1 | metH | HMPREF0758_0297 | HMPREF0758_1689 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.972 |
| XecA1 | metK | HMPREF0758_0297 | HMPREF0758_2175 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.959 |
| XecA1 | mmuM | HMPREF0758_0297 | HMPREF0758_2638 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Homocysteine S-methyltransferase; COG: COG2040; Pfam: PF02574; InterPro: IPR003726. | 0.912 |
| XecA1 | yxjG | HMPREF0758_0297 | HMPREF0758_0243 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Methionine synthase, vitamin-B12 independent; COG: COG0620; Pfam: PF01717. | 0.919 |
| luxS | XecA1 | HMPREF0758_0419 | HMPREF0758_0297 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | 0.914 |
| luxS | metB | HMPREF0758_0419 | HMPREF0758_1161 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Cystathionine gamma-synthase; COG: COG0626; Pfam: PF01053; InterPro: IPR011821. | 0.935 |
| luxS | metC | HMPREF0758_0419 | HMPREF0758_0469 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Putative methionine gamma-lyase; COG: COG0626; Pfam: PF01053; InterPro: IPR000277. | 0.936 |
| luxS | metC-2 | HMPREF0758_0419 | HMPREF0758_1976 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Cystathionine beta-lyase; COG: COG0626; Pfam: PF01053; InterPro: IPR006233. | 0.939 |
| luxS | metC-3 | HMPREF0758_0419 | HMPREF0758_2010 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Cystathionine beta-lyase; COG: COG0626; Pfam: PF01053; InterPro: IPR006233. | 0.934 |
| luxS | metC5 | HMPREF0758_0419 | HMPREF0758_4526 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Cys/Met metabolism PLP-dependent enzyme; COG: COG0626; Pfam: PF01053; InterPro: IPR000277. | 0.865 |
| luxS | metH | HMPREF0758_0419 | HMPREF0758_1689 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.951 |
| luxS | metK | HMPREF0758_0419 | HMPREF0758_2175 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.429 |
| luxS | mmuM | HMPREF0758_0419 | HMPREF0758_2638 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Homocysteine S-methyltransferase; COG: COG2040; Pfam: PF02574; InterPro: IPR003726. | 0.917 |
| luxS | yxjG | HMPREF0758_0419 | HMPREF0758_0243 | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Methionine synthase, vitamin-B12 independent; COG: COG0620; Pfam: PF01717. | 0.933 |