| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE97967.1 | EFE97968.1 | HMPREF0758_0295 | HMPREF0758_0296 | Hypothetical protein; Pfam: PF08908; InterPro: IPR015004. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | 0.888 |
| EFE97967.1 | XecA1 | HMPREF0758_0295 | HMPREF0758_0297 | Hypothetical protein; Pfam: PF08908; InterPro: IPR015004. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | 0.888 |
| EFE97968.1 | EFE97967.1 | HMPREF0758_0296 | HMPREF0758_0295 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | Hypothetical protein; Pfam: PF08908; InterPro: IPR015004. | 0.888 |
| EFE97968.1 | XecA1 | HMPREF0758_0296 | HMPREF0758_0297 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | 0.994 |
| EFE97968.1 | metA | HMPREF0758_0296 | HMPREF0758_1681 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.400 |
| EFE97968.1 | metF | HMPREF0758_0296 | HMPREF0758_1158 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family. | 0.702 |
| EFE97968.1 | metH | HMPREF0758_0296 | HMPREF0758_1689 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.734 |
| EFE97968.1 | metK | HMPREF0758_0296 | HMPREF0758_2175 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.607 |
| EFE97968.1 | metL | HMPREF0758_0296 | HMPREF0758_1159 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | Homoserine dehydrogenase; COG: COG0460; Pfam: PF00742; InterPro: IPR001342. | 0.474 |
| EFE97968.1 | metM2 | HMPREF0758_0296 | HMPREF0758_1160 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | Amino acid kinase family; COG: COG0527; Pfam: PF00696; InterPro: IPR001341. | 0.474 |
| EFE97968.1 | thrA | HMPREF0758_0296 | HMPREF0758_0591 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.474 |
| XecA1 | EFE97967.1 | HMPREF0758_0297 | HMPREF0758_0295 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Hypothetical protein; Pfam: PF08908; InterPro: IPR015004. | 0.888 |
| XecA1 | EFE97968.1 | HMPREF0758_0297 | HMPREF0758_0296 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; overlaps another CDS with the same product name. | 0.994 |
| XecA1 | metA | HMPREF0758_0297 | HMPREF0758_1681 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.400 |
| XecA1 | metF | HMPREF0758_0297 | HMPREF0758_1158 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Methylenetetrahydrofolate reductase (NAD(P)H); COG: COG0685; Pfam: PF02219; InterPro: IPR003171; Belongs to the methylenetetrahydrofolate reductase family. | 0.702 |
| XecA1 | metH | HMPREF0758_0297 | HMPREF0758_1689 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.972 |
| XecA1 | metK | HMPREF0758_0297 | HMPREF0758_2175 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.959 |
| XecA1 | metL | HMPREF0758_0297 | HMPREF0758_1159 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Homoserine dehydrogenase; COG: COG0460; Pfam: PF00742; InterPro: IPR001342. | 0.474 |
| XecA1 | metM2 | HMPREF0758_0297 | HMPREF0758_1160 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Amino acid kinase family; COG: COG0527; Pfam: PF00696; InterPro: IPR001341. | 0.890 |
| XecA1 | thrA | HMPREF0758_0297 | HMPREF0758_0591 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name. | Homoserine dehydrogenase; COG: COG0527; Pfam: PF00696,PF01842,PF03447,PF00742; InterPro: IPR001341; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.890 |