STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
luxSS-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)    
Predicted Functional Partners:
mtnN
MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...]
 
 
 0.985
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.951
metC-2
Cystathionine beta-lyase; COG: COG0626; Pfam: PF01053; InterPro: IPR006233.
 
 
 0.939
metC
Putative methionine gamma-lyase; COG: COG0626; Pfam: PF01053; InterPro: IPR000277.
 
 
 0.936
cysB2
Putative cystathionine beta-synthase; COG: COG0031; Pfam: PF00291,PF00571; InterPro: IPR001926.
  
 
 0.936
metB
Cystathionine gamma-synthase; COG: COG0626; Pfam: PF01053; InterPro: IPR011821.
 
 
 0.935
metC-3
Cystathionine beta-lyase; COG: COG0626; Pfam: PF01053; InterPro: IPR006233.
 
 
 0.934
yxjG
Methionine synthase, vitamin-B12 independent; COG: COG0620; Pfam: PF01717.
 
  
 0.933
mmuM
Homocysteine S-methyltransferase; COG: COG2040; Pfam: PF02574; InterPro: IPR003726.
     
 0.917
XecA1
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase family protein; COG: COG0620; Pfam: PF01717; InterPro: IPR002629; overlaps another CDS with the same product name.
    
 0.914
Your Current Organism:
Serratia odorifera
NCBI taxonomy Id: 667129
Other names: S. odorifera DSM 4582, Serratia odorifera DSM 4582, Serratia odorifera str. DSM 4582, Serratia odorifera strain DSM 4582
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