| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE97848.1 | RpoS | HMPREF0758_0432 | HMPREF0758_0433 | Sigma-70, region 4; COG: COG0568; Pfam: PF04539,PF04545; InterPro: IPR011991. | Sigma-70 region 2; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.991 |
| EFE97848.1 | nlpD | HMPREF0758_0432 | HMPREF0758_0434 | Sigma-70, region 4; COG: COG0568; Pfam: PF04539,PF04545; InterPro: IPR011991. | Peptidase, M23 family; COG: COG0739; Pfam: PF01476,PF01551; InterPro: IPR002886. | 0.722 |
| EFE97848.1 | pcm | HMPREF0758_0432 | HMPREF0758_0435 | Sigma-70, region 4; COG: COG0568; Pfam: PF04539,PF04545; InterPro: IPR011991. | protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | 0.433 |
| RpoS | EFE97848.1 | HMPREF0758_0433 | HMPREF0758_0432 | Sigma-70 region 2; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Sigma-70, region 4; COG: COG0568; Pfam: PF04539,PF04545; InterPro: IPR011991. | 0.991 |
| RpoS | nlpD | HMPREF0758_0433 | HMPREF0758_0434 | Sigma-70 region 2; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Peptidase, M23 family; COG: COG0739; Pfam: PF01476,PF01551; InterPro: IPR002886. | 0.764 |
| RpoS | pcm | HMPREF0758_0433 | HMPREF0758_0435 | Sigma-70 region 2; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | 0.456 |
| RpoS | surE | HMPREF0758_0433 | HMPREF0758_0436 | Sigma-70 region 2; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.406 |
| amiB | amiC | HMPREF0758_0868 | HMPREF0758_2308 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | 0.931 |
| amiB | amiC2 | HMPREF0758_0868 | HMPREF0758_2643 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | 0.927 |
| amiB | nlpD | HMPREF0758_0868 | HMPREF0758_0434 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | Peptidase, M23 family; COG: COG0739; Pfam: PF01476,PF01551; InterPro: IPR002886. | 0.748 |
| amiC | amiB | HMPREF0758_2308 | HMPREF0758_0868 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | 0.931 |
| amiC | amiC2 | HMPREF0758_2308 | HMPREF0758_2643 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | 0.910 |
| amiC | nlpD | HMPREF0758_2308 | HMPREF0758_0434 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | Peptidase, M23 family; COG: COG0739; Pfam: PF01476,PF01551; InterPro: IPR002886. | 0.476 |
| amiC2 | amiB | HMPREF0758_2643 | HMPREF0758_0868 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520,PF01476; InterPro: IPR002508. | 0.927 |
| amiC2 | amiC | HMPREF0758_2643 | HMPREF0758_2308 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | 0.910 |
| amiC2 | nlpD | HMPREF0758_2643 | HMPREF0758_0434 | N-acetylmuramoyl-L-alanine amidase; COG: COG0860; Pfam: PF01520; InterPro: IPR002508. | Peptidase, M23 family; COG: COG0739; Pfam: PF01476,PF01551; InterPro: IPR002886. | 0.488 |
| ftsB | nlpD | HMPREF0758_0440 | HMPREF0758_0434 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Peptidase, M23 family; COG: COG0739; Pfam: PF01476,PF01551; InterPro: IPR002886. | 0.509 |
| ftsB | pcm | HMPREF0758_0440 | HMPREF0758_0435 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. | 0.794 |
| ftsB | surE | HMPREF0758_0440 | HMPREF0758_0436 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.794 |
| lepB | nlpD | HMPREF0758_2454 | HMPREF0758_0434 | Signal peptidase I; COG: COG0681; Pfam: PF00717; InterPro: IPR011056; Belongs to the peptidase S26 family. | Peptidase, M23 family; COG: COG0739; Pfam: PF01476,PF01551; InterPro: IPR002886. | 0.614 |