| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| YcbX_2 | cysI | HMPREF0758_4350 | HMPREF0758_0451 | MOSC domain protein; COG: COG3217; Pfam: PF03476,PF03473,PF00111; InterPro: IPR005302. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.710 |
| YcbX_2 | cysJ | HMPREF0758_4350 | HMPREF0758_0452 | MOSC domain protein; COG: COG3217; Pfam: PF03476,PF03473,PF00111; InterPro: IPR005302. | Sulfite reductase (NADPH) flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. | 0.936 |
| cysC | cysD | HMPREF0758_0445 | HMPREF0758_0447 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | 0.999 |
| cysC | cysH | HMPREF0758_0445 | HMPREF0758_0450 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.997 |
| cysC | cysI | HMPREF0758_0445 | HMPREF0758_0451 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.963 |
| cysC | cysJ | HMPREF0758_0445 | HMPREF0758_0452 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase (NADPH) flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. | 0.943 |
| cysC | cysK | HMPREF0758_0445 | HMPREF0758_0190 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Pyridoxal-phosphate dependent protein; COG: COG0031; Pfam: PF00291; InterPro: IPR001926. | 0.452 |
| cysC | cysK-2 | HMPREF0758_0445 | HMPREF0758_2660 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Cysteine synthase A; COG: COG0031; Pfam: PF00291; InterPro: IPR001926; overlaps another CDS with the same product name. | 0.452 |
| cysC | cysN | HMPREF0758_0445 | HMPREF0758_0446 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.999 |
| cysC | cysP | HMPREF0758_0445 | HMPREF0758_2649 | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfate ABC transporter, sulfate-binding protein; COG: COG4150; Pfam: PF01547; InterPro: IPR005669. | 0.910 |
| cysD | cysC | HMPREF0758_0447 | HMPREF0758_0445 | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.999 |
| cysD | cysH | HMPREF0758_0447 | HMPREF0758_0450 | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.969 |
| cysD | cysI | HMPREF0758_0447 | HMPREF0758_0451 | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.936 |
| cysD | cysJ | HMPREF0758_0447 | HMPREF0758_0452 | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | Sulfite reductase (NADPH) flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. | 0.954 |
| cysD | cysK | HMPREF0758_0447 | HMPREF0758_0190 | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | Pyridoxal-phosphate dependent protein; COG: COG0031; Pfam: PF00291; InterPro: IPR001926. | 0.628 |
| cysD | cysK-2 | HMPREF0758_0447 | HMPREF0758_2660 | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | Cysteine synthase A; COG: COG0031; Pfam: PF00291; InterPro: IPR001926; overlaps another CDS with the same product name. | 0.576 |
| cysD | cysN | HMPREF0758_0447 | HMPREF0758_0446 | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.999 |
| cysD | cysP | HMPREF0758_0447 | HMPREF0758_2649 | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | Sulfate ABC transporter, sulfate-binding protein; COG: COG4150; Pfam: PF01547; InterPro: IPR005669. | 0.994 |
| cysH | cysC | HMPREF0758_0450 | HMPREF0758_0445 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.997 |
| cysH | cysD | HMPREF0758_0450 | HMPREF0758_0447 | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784. | 0.969 |