| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gcvP | hutH | HMPREF0758_2216 | HMPREF0758_0463 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Histidine ammonia-lyase; COG: COG2986; Pfam: PF00221; InterPro: IPR005921. | 0.557 |
| gcvP | speB | HMPREF0758_2216 | HMPREF0758_2177 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Agmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. | 0.410 |
| hisD | hutH | HMPREF0758_4534 | HMPREF0758_0463 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Histidine ammonia-lyase; COG: COG2986; Pfam: PF00221; InterPro: IPR005921. | 0.922 |
| hutC | hutF | HMPREF0758_4031 | HMPREF0758_4030 | Histidine utilization repressor; COG: COG2188; Pfam: PF00392,PF07702; InterPro: IPR010248. | Formimidoylglutamate deiminase; COG: COG0402; Pfam: PF01979; InterPro: IPR010252. | 0.799 |
| hutC | hutG | HMPREF0758_4031 | HMPREF0758_4033 | Histidine utilization repressor; COG: COG2188; Pfam: PF00392,PF07702; InterPro: IPR010248. | N-formylglutamate deformylase; COG: COG3741; Pfam: PF05013; InterPro: IPR010247. | 0.925 |
| hutC | hutH | HMPREF0758_4031 | HMPREF0758_0463 | Histidine utilization repressor; COG: COG2188; Pfam: PF00392,PF07702; InterPro: IPR010248. | Histidine ammonia-lyase; COG: COG2986; Pfam: PF00221; InterPro: IPR005921. | 0.694 |
| hutC | hutI | HMPREF0758_4031 | HMPREF0758_4032 | Histidine utilization repressor; COG: COG2188; Pfam: PF00392,PF07702; InterPro: IPR010248. | Imidazolonepropionase; COG: COG1228; Pfam: PF01979; InterPro: IPR005920. | 0.951 |
| hutC | hutU | HMPREF0758_4031 | HMPREF0758_0462 | Histidine utilization repressor; COG: COG2188; Pfam: PF00392,PF07702; InterPro: IPR010248. | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. | 0.760 |
| hutF | hutC | HMPREF0758_4030 | HMPREF0758_4031 | Formimidoylglutamate deiminase; COG: COG0402; Pfam: PF01979; InterPro: IPR010252. | Histidine utilization repressor; COG: COG2188; Pfam: PF00392,PF07702; InterPro: IPR010248. | 0.799 |
| hutF | hutG | HMPREF0758_4030 | HMPREF0758_4033 | Formimidoylglutamate deiminase; COG: COG0402; Pfam: PF01979; InterPro: IPR010252. | N-formylglutamate deformylase; COG: COG3741; Pfam: PF05013; InterPro: IPR010247. | 0.989 |
| hutF | hutH | HMPREF0758_4030 | HMPREF0758_0463 | Formimidoylglutamate deiminase; COG: COG0402; Pfam: PF01979; InterPro: IPR010252. | Histidine ammonia-lyase; COG: COG2986; Pfam: PF00221; InterPro: IPR005921. | 0.659 |
| hutF | hutI | HMPREF0758_4030 | HMPREF0758_4032 | Formimidoylglutamate deiminase; COG: COG0402; Pfam: PF01979; InterPro: IPR010252. | Imidazolonepropionase; COG: COG1228; Pfam: PF01979; InterPro: IPR005920. | 0.989 |
| hutF | hutU | HMPREF0758_4030 | HMPREF0758_0462 | Formimidoylglutamate deiminase; COG: COG0402; Pfam: PF01979; InterPro: IPR010252. | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. | 0.778 |
| hutG | hutC | HMPREF0758_4033 | HMPREF0758_4031 | N-formylglutamate deformylase; COG: COG3741; Pfam: PF05013; InterPro: IPR010247. | Histidine utilization repressor; COG: COG2188; Pfam: PF00392,PF07702; InterPro: IPR010248. | 0.925 |
| hutG | hutF | HMPREF0758_4033 | HMPREF0758_4030 | N-formylglutamate deformylase; COG: COG3741; Pfam: PF05013; InterPro: IPR010247. | Formimidoylglutamate deiminase; COG: COG0402; Pfam: PF01979; InterPro: IPR010252. | 0.989 |
| hutG | hutH | HMPREF0758_4033 | HMPREF0758_0463 | N-formylglutamate deformylase; COG: COG3741; Pfam: PF05013; InterPro: IPR010247. | Histidine ammonia-lyase; COG: COG2986; Pfam: PF00221; InterPro: IPR005921. | 0.532 |
| hutG | hutI | HMPREF0758_4033 | HMPREF0758_4032 | N-formylglutamate deformylase; COG: COG3741; Pfam: PF05013; InterPro: IPR010247. | Imidazolonepropionase; COG: COG1228; Pfam: PF01979; InterPro: IPR005920. | 0.969 |
| hutG | hutU | HMPREF0758_4033 | HMPREF0758_0462 | N-formylglutamate deformylase; COG: COG3741; Pfam: PF05013; InterPro: IPR010247. | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. | 0.713 |
| hutG | proX | HMPREF0758_4033 | HMPREF0758_0465 | N-formylglutamate deformylase; COG: COG3741; Pfam: PF05013; InterPro: IPR010247. | ABC transporter, substrate-binding protein, QAT family; COG: COG2113; Pfam: PF04069; InterPro: IPR007210. | 0.621 |
| hutH | gcvP | HMPREF0758_0463 | HMPREF0758_2216 | Histidine ammonia-lyase; COG: COG2986; Pfam: PF00221; InterPro: IPR005921. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.557 |