| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFE97935.1 | ftsA | HMPREF0758_0519 | HMPREF0758_0509 | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | 0.722 |
| EFE97935.1 | ftsB | HMPREF0758_0519 | HMPREF0758_0440 | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.415 |
| EFE97935.1 | ftsI | HMPREF0758_0519 | HMPREF0758_0520 | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | 0.990 |
| EFE97935.1 | ftsL | HMPREF0758_0519 | HMPREF0758_0521 | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.780 |
| EFE97935.1 | ftsQ | HMPREF0758_0519 | HMPREF0758_0510 | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.833 |
| EFE97935.1 | ftsW | HMPREF0758_0519 | HMPREF0758_0514 | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.946 |
| EFE97935.1 | mraW | HMPREF0758_0519 | HMPREF0758_0522 | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.748 |
| EFE97935.1 | mraZ | HMPREF0758_0519 | HMPREF0758_0523 | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | Protein MraZ; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. | 0.731 |
| EFE97935.1 | murE | HMPREF0758_0519 | HMPREF0758_0518 | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.922 |
| ftsA | EFE97935.1 | HMPREF0758_0509 | HMPREF0758_0519 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | 0.722 |
| ftsA | ftsB | HMPREF0758_0509 | HMPREF0758_0440 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.479 |
| ftsA | ftsI | HMPREF0758_0509 | HMPREF0758_0520 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Penicillin-binding protein dimerization domain protein; COG: COG0768; Pfam: PF03717,PF00905; InterPro: IPR005311. | 0.761 |
| ftsA | ftsL | HMPREF0758_0509 | HMPREF0758_0521 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.733 |
| ftsA | ftsQ | HMPREF0758_0509 | HMPREF0758_0510 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.986 |
| ftsA | ftsW | HMPREF0758_0509 | HMPREF0758_0514 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.929 |
| ftsA | mraW | HMPREF0758_0509 | HMPREF0758_0522 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. | 0.714 |
| ftsA | mraZ | HMPREF0758_0509 | HMPREF0758_0523 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Protein MraZ; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. | 0.718 |
| ftsA | murE | HMPREF0758_0509 | HMPREF0758_0518 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.880 |
| ftsA | zipA | HMPREF0758_0509 | HMPREF0758_2662 | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | ZipA, C-terminal FtsZ-binding domain protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.480 |
| ftsB | EFE97935.1 | HMPREF0758_0440 | HMPREF0758_0519 | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | Hypothetical protein; COG: COG0768; Pfam: PF00905; InterPro: IPR001460; 2.4.1.129. | 0.415 |