| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aad | grcA | HMPREF0758_3517 | HMPREF0758_2443 | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Glycine radical domain protein; Acts as a radical domain for damaged PFL and possibly other radical proteins. | 0.698 |
| aad | guaA-2 | HMPREF0758_3517 | HMPREF0758_2515 | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.512 |
| aad | nrdD | HMPREF0758_3517 | HMPREF0758_0763 | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477,PF01228; InterPro: IPR012833. | 0.526 |
| aad | nrdG-2 | HMPREF0758_3517 | HMPREF0758_0764 | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.511 |
| exsB | exsB2 | HMPREF0758_0194 | HMPREF0758_5058 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.901 |
| exsB | nrdG-2 | HMPREF0758_0194 | HMPREF0758_0764 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.587 |
| exsB | queD | HMPREF0758_0194 | HMPREF0758_0459 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.891 |
| exsB | queF | HMPREF0758_0194 | HMPREF0758_1989 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.979 |
| exsB | queF-2 | HMPREF0758_0194 | HMPREF0758_2319 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.978 |
| exsB2 | exsB | HMPREF0758_5058 | HMPREF0758_0194 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.901 |
| exsB2 | nrdG-2 | HMPREF0758_5058 | HMPREF0758_0764 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.587 |
| exsB2 | queD | HMPREF0758_5058 | HMPREF0758_0459 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.890 |
| exsB2 | queF | HMPREF0758_5058 | HMPREF0758_1989 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.979 |
| exsB2 | queF-2 | HMPREF0758_5058 | HMPREF0758_2319 | Protein ExsB; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.978 |
| folE | nrdD | HMPREF0758_4594 | HMPREF0758_0763 | GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328; Pfam: PF03477,PF01228; InterPro: IPR012833. | 0.800 |
| folE | nrdG-2 | HMPREF0758_4594 | HMPREF0758_0764 | GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474. | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.513 |
| folE | queD | HMPREF0758_4594 | HMPREF0758_0459 | GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474. | Queuosine biosynthesis protein QueD; COG: COG0720; Pfam: PF01242; InterPro: IPR007115. | 0.982 |
| folE | queF | HMPREF0758_4594 | HMPREF0758_1989 | GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.485 |
| folE | queF-2 | HMPREF0758_4594 | HMPREF0758_2319 | GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474. | Queuine synthase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.485 |
| grcA | aad | HMPREF0758_2443 | HMPREF0758_3517 | Glycine radical domain protein; Acts as a radical domain for damaged PFL and possibly other radical proteins. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1454; Pfam: PF00171,PF00465; InterPro: IPR001670; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.698 |